Figure 2

WGAS rank asymmetries for specific biological processes. (a) Graphical representation of over- and/or under-representation of biological processes in partitions of WGAS ranks using Level 3 GO annotations. Top left panel, results of the analysis of the WGAS rank according to the lowest P value per gene locus. Differences are always shown from top to bottom, so the top shows over-representation in the GO terms Transport and Cell Communication. Graphics show significant partitions. Bottom left panel, graphical representation of the positions of genes annotated with GO terms distributed asymmetrically in the WGAS P value rank. Right panels, results of the analysis of the WGAS rank according to ORs and to P values. This analysis seems to better capture the differences in risk (ORs > 1) associated with the over-representation of Cell Adhesion. Under-representation (negative differences when comparing top with bottom parts) of Metabolic processes annotations is also suggested with ORs of > 1. The graphical representation of gene positions shows clear differences between Cell Adhesion and more complex patterns – perhaps with different gene subgroups – for Cell Communication and Metabolic processes. (b) Graphical representation of over- and/or under-representation of biological processes in partitions of WGAS ranks using Level 4 GO annotations. Left panel, child terms of Cell Communication (Signal Transduction), Transport (Ion Transport) and Cell Adhesion (rest of terms shown in the inset) are over-represented at P values of up to 0.262. Right panel, over-representations in the WGAS OR/P value ordered list as shown in the insets.