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Table 3 Z-score reports for selected gene ontologies represented in the transcription profile of pterostilbene-treated yeast cells

From: Identification of molecular pathways affected by pterostilbene, a natural dimethylether analog of resveratrol

Ontology Genes Up Down Array z-up z-down
Biological process       
   Biosynthesis 150 104 46 871 -2.73 2.7
   Response to stress 83 76 7 365 3.35 -1.92
Response to drug 13 13 0 26 5.05 -1.01
   Amino acid and derivative metabolism 42 22 20 189 -1.27 5.08
Sulfur amino acid metabolism 14 2 12 30 -1.27 10.5
Aspartate family amino acid metabolism 14 1 13 41 -2.25 9.48
Methionine metabolism 11 0 11 21 -1.92 11.78
   Regulation of transcription from Pol II promoter 40 36 4 169 2.4 -0.96
   Reproduction 32 18 14 176 -1.77 3.01
   Ion transport 27 18 9 104 0.71 2.68
   Regulation of cell cycle 24 15 9 122 -0.81 2.15
   Mitochondrion organization and biogenesis 20 18 2 77 2.12 -0.53
   Protein folding 19 17 2 46 4.24 0.22
Molecular function       
   Transferase activity 99 67 32 604 -2.76 2.11
   Transporter activity 87 63 24 406 0.49 2.36
Ion transporter activity 27 18 9 121 0.05 2.13
Organic acid transporter activity 12 7 5 46 0.1 2.52
ATP-binding cassette (ABC) transporter activity 10 10 0 29 3.02 -1.08
   Oxidoreductase activity 59 38 21 236 0.63 4.23
   ATPase activity 33 33 0 158 2.24 -2.56
   Peptidase activity 25 25 0 116 2.12 -2.18
   Chaperone activity 24 24 0 85 3.56 -1.86
   Transcription factor activity 21 20 1 54 4.67 -0.76
   Kinase regulator activity 12 5 7 36 -0.14 4.93
Cellular component       
   Mitochondrion 161 148 13 644 6.1 -2.23
   Plasma membrane 57 38 19 215 1.13 4.31
   Endoplasmic reticulum 52 37 15 364 -2.68 0.63
   Cytosol 38 26 12 390 -4.8 -0.51
   Cell wall 36 18 18 95 1.09 8.22
   Chromosome 22 14 8 182 -2.81 0.64
   Cytoskeleton 22 16 6 194 -2.68 -0.34
  1. Z-scores were determined using GeneSifter software. Criteria for inclusion in the table were an ontology having a z-score ≥ 2 or ≤ -2 and containing ≥ 10 genes. Genes, number of genes differentially expressed within the assigned ontology; array, the number of genes on the microarray assigned to the particular gene ontology. Sub-categories within a given ontology are shown in italics. Significant z-scores and corresponding numbers of genes in each category are shown in bold.