Identification of molecular pathways affected by pterostilbene, a natural dimethylether analog of resveratrol

BMC Medical Genomics

Table 3 Z-score reports for selected gene ontologies represented in the transcription profile of pterostilbene-treated yeast cells

Ontology	Genes	Up	Down	Array	z-up	z-down
Biological process
Biosynthesis	150	104	46	871	-2.73	2.7
Response to stress	83	76	7	365	3.35	-1.92
Response to drug	13	13	0	26	*5.05*	-1.01
Amino acid and derivative metabolism	42	22	20	189	-1.27	5.08
Sulfur amino acid metabolism	14	2	12	30	-1.27	*10.5*
Aspartate family amino acid metabolism	14	1	13	41	-2.25	*9.48*
Methionine metabolism	11	0	11	21	-1.92	*11.78*
Regulation of transcription from Pol II promoter	40	36	4	169	2.4	-0.96
Reproduction	32	18	14	176	-1.77	3.01
Ion transport	27	18	9	104	0.71	2.68
Regulation of cell cycle	24	15	9	122	-0.81	2.15
Mitochondrion organization and biogenesis	20	18	2	77	2.12	-0.53
Protein folding	19	17	2	46	4.24	0.22
Molecular function
Transferase activity	99	67	32	604	-2.76	2.11
Transporter activity	87	63	24	406	0.49	2.36
Ion transporter activity	27	18	9	121	0.05	*2.13*
Organic acid transporter activity	12	7	5	46	0.1	*2.52*
ATP-binding cassette (ABC) transporter activity	10	10	0	29	*3.02*	-1.08
Oxidoreductase activity	59	38	21	236	0.63	4.23
ATPase activity	33	33	0	158	2.24	-2.56
Peptidase activity	25	25	0	116	2.12	-2.18
Chaperone activity	24	24	0	85	3.56	-1.86
Transcription factor activity	21	20	1	54	4.67	-0.76
Kinase regulator activity	12	5	7	36	-0.14	4.93
Cellular component
Mitochondrion	161	148	13	644	6.1	-2.23
Plasma membrane	57	38	19	215	1.13	4.31
Endoplasmic reticulum	52	37	15	364	-2.68	0.63
Cytosol	38	26	12	390	-4.8	-0.51
Cell wall	36	18	18	95	1.09	8.22
Chromosome	22	14	8	182	-2.81	0.64
Cytoskeleton	22	16	6	194	-2.68	-0.34

Z-scores were determined using GeneSifter software. Criteria for inclusion in the table were an ontology having a z-score ≥ 2 or ≤ -2 and containing ≥ 10 genes. Genes, number of genes differentially expressed within the assigned ontology; array, the number of genes on the microarray assigned to the particular gene ontology. Sub-categories within a given ontology are shown in italics. Significant z-scores and corresponding numbers of genes in each category are shown in bold.

ISSN: 1755-8794