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Table 4 Pterostilbene-responsive genes involved in lipid metabolism

From: Identification of molecular pathways affected by pterostilbene, a natural dimethylether analog of resveratrol

Accession Gene Ratio p-value Gene Description
a. Lipid biosynthesis/metabolism process
   YBR004C GPI18 3.1 1.28 × 10-4 Functional ortholog of human PIG-V
   YGL126W SCS3 2.4 1.06 × 10-3 Required for inositol prototrophy
   YDR173C ARG82 2.3 2.53 × 10-4 Inositol polyphosphate multikinase (IPMK)
   YGR036C CAX4 2.3 0.02 Dolichyl pyrophosphate (Dol-P-P) phosphatase
   YIL124W AYR1 -2.7 6.79 × 10-4 1-acyl dihydroxyacetone phosphate reductase
   YJL153C INO1 10.0 6.73 × 10-4 L-myo-inositol-1-phosphate synthase
   YJL196C ELO1 -2.8 1.18 × 10-5 Elongase
   YKL051W SFK1 4.0 4.36 × 10-4 Suppressor of PI Four Kinase
   YMR165C PAH1 2.2 1.15 × 10-3 Mg2+-dependent phosphatidate (PA) phosphatase
   YMR207C HFA1 2.0 3.22 × 10-4 Mitochondrial acetyl-coenzyme A carboxylase
   YNL169C PSD1 -2.1 1.93 × 10-3 Phosphatidylserine decarboxylase
   YNL231C PDR16 6.1 3.54 × 10-4 by the multiple drug resistance regulator Pdr1p
   YNR043W MVD1 -2.2 3.55 × 10-4 Mevalonate pyrophosphate decarboxylase
   YPR183W DPM1 -2.3 2.88 × 10-4 Dolichol phosphate mannose synthase
   YKR009C FOX2 3.1 7.82 × 10-4 Multifunctional beta-oxidation protein
   YLR284C ECI1 2.1 8.91 × 10-3 Peroxisomal Δ3, Δ2-enoyl-CoA isomerase
   YML042W CAT2 2.4 2.21 × 10-4 Carnitine O-acetyltransferase
   YMR246W FAA4 2.1 1.25 × 10-4 Long chain fatty acyl-CoA synthetase
   YNR019W ARE2 4.1 1.28 × 10-4 Acyl-CoA:sterol acyltransferase
   YOR100C CRC1 2.4 0.01 Carnitine transporter
   YKR031C SPO14 2.1 1.36 × 10-3 Phospholipase D
   YMR008C PLB1 3.9 3.37 × 10-4 Phospholipase B (lypophospholipase)
b. Sphingolipid metabolism
   YBR265W TSC10 -2.4 5.46 × 10-4 3-ketosphinganine reductase
   YCR034W FEN1 -3.0 3.49 × 10-4 Fatty acid elongase
   YDR062W LCB2 -2.1 5.13 × 10-4 Component of serine palmitoyltransferase
   YDR072C IPT1 6.5 2.64 × 10-6 Inositolphosphotransferase 1
   YLR260W LCB5 3.7 8.66 × 10-4 Minor sphingoid long-chain base kinase
   YOR171C LCB4 2.6 8 × 10-5 Sphingoid long-chain base kinase
   YPL057C SUR1 3.5 4.67 × 10-3 Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase
   YPL087W YDC1 2.2 2.93 × 10-3 Alkaline dihydroceramidase
c. Genes involved in the regulation of lipid biosynthesis and metabolism
   YAL051W OAF1 2.0 1.1 × 10-3 Oleate-activated transcription factor
   YDR096W GIS1 4.0 2.12 × 10-3 Transcriptional factor
   YDR213W UPC2 8.8 6.78 × 10-5 Sterol regulatory element binding protein
   YOR237W HES1 3.1 4.32 × 10-3 Protein implicated in the regulation of ergosterol biosynthesis;
   YIR033W MGA2 2.0 1.53 × 10-3 ER membrane protein involved in regulation of OLE1 transcription
   YKL020C SPT23 2.1 7.73 × 10-4 ER membrane protein involved in regulation of OLE1 transcription
   YOR049C RSB1 131.8 2.23 × 10-4 Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation
   YOL108C INO4 2.1 5.1 × 10-3 Transcription factor required for derepression of inositol-choline-regulated genes