Table 4 Pterostilbene-responsive genes involved in lipid metabolism
Accession | Gene | Ratio | p-value | Gene Description |
|---|---|---|---|---|
a. Lipid biosynthesis/metabolism process | ||||
   YBR004C | GPI18 | 3.1 | 1.28 × 10-4 | Functional ortholog of human PIG-V |
   YGL126W | SCS3 | 2.4 | 1.06 × 10-3 | Required for inositol prototrophy |
   YDR173C | ARG82 | 2.3 | 2.53 × 10-4 | Inositol polyphosphate multikinase (IPMK) |
   YGR036C | CAX4 | 2.3 | 0.02 | Dolichyl pyrophosphate (Dol-P-P) phosphatase |
   YIL124W | AYR1 | -2.7 | 6.79 × 10-4 | 1-acyl dihydroxyacetone phosphate reductase |
   YJL153C | INO1 | 10.0 | 6.73 × 10-4 | L-myo-inositol-1-phosphate synthase |
   YJL196C | ELO1 | -2.8 | 1.18 × 10-5 | Elongase |
   YKL051W | SFK1 | 4.0 | 4.36 × 10-4 | Suppressor of PI Four Kinase |
   YMR165C | PAH1 | 2.2 | 1.15 × 10-3 | Mg2+-dependent phosphatidate (PA) phosphatase |
   YMR207C | HFA1 | 2.0 | 3.22 × 10-4 | Mitochondrial acetyl-coenzyme A carboxylase |
   YNL169C | PSD1 | -2.1 | 1.93 × 10-3 | Phosphatidylserine decarboxylase |
   YNL231C | PDR16 | 6.1 | 3.54 × 10-4 | by the multiple drug resistance regulator Pdr1p |
   YNR043W | MVD1 | -2.2 | 3.55 × 10-4 | Mevalonate pyrophosphate decarboxylase |
   YPR183W | DPM1 | -2.3 | 2.88 × 10-4 | Dolichol phosphate mannose synthase |
   YKR009C | FOX2 | 3.1 | 7.82 × 10-4 | Multifunctional beta-oxidation protein |
   YLR284C | ECI1 | 2.1 | 8.91 × 10-3 | Peroxisomal Δ3, Δ2-enoyl-CoA isomerase |
   YML042W | CAT2 | 2.4 | 2.21 × 10-4 | Carnitine O-acetyltransferase |
   YMR246W | FAA4 | 2.1 | 1.25 × 10-4 | Long chain fatty acyl-CoA synthetase |
   YNR019W | ARE2 | 4.1 | 1.28 × 10-4 | Acyl-CoA:sterol acyltransferase |
   YOR100C | CRC1 | 2.4 | 0.01 | Carnitine transporter |
   YKR031C | SPO14 | 2.1 | 1.36 × 10-3 | Phospholipase D |
   YMR008C | PLB1 | 3.9 | 3.37 × 10-4 | Phospholipase B (lypophospholipase) |
b. Sphingolipid metabolism | ||||
   YBR265W | TSC10 | -2.4 | 5.46 × 10-4 | 3-ketosphinganine reductase |
   YCR034W | FEN1 | -3.0 | 3.49 × 10-4 | Fatty acid elongase |
   YDR062W | LCB2 | -2.1 | 5.13 × 10-4 | Component of serine palmitoyltransferase |
   YDR072C | IPT1 | 6.5 | 2.64 × 10-6 | Inositolphosphotransferase 1 |
   YLR260W | LCB5 | 3.7 | 8.66 × 10-4 | Minor sphingoid long-chain base kinase |
   YOR171C | LCB4 | 2.6 | 8 × 10-5 | Sphingoid long-chain base kinase |
   YPL057C | SUR1 | 3.5 | 4.67 × 10-3 | Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase |
   YPL087W | YDC1 | 2.2 | 2.93 × 10-3 | Alkaline dihydroceramidase |
c. Genes involved in the regulation of lipid biosynthesis and metabolism | ||||
   YAL051W | OAF1 | 2.0 | 1.1 × 10-3 | Oleate-activated transcription factor |
   YDR096W | GIS1 | 4.0 | 2.12 × 10-3 | Transcriptional factor |
   YDR213W | UPC2 | 8.8 | 6.78 × 10-5 | Sterol regulatory element binding protein |
   YOR237W | HES1 | 3.1 | 4.32 × 10-3 | Protein implicated in the regulation of ergosterol biosynthesis; |
   YIR033W | MGA2 | 2.0 | 1.53 × 10-3 | ER membrane protein involved in regulation of OLE1 transcription |
   YKL020C | SPT23 | 2.1 | 7.73 × 10-4 | ER membrane protein involved in regulation of OLE1 transcription |
   YOR049C | RSB1 | 131.8 | 2.23 × 10-4 | Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation |
   YOL108C | INO4 | 2.1 | 5.1 × 10-3 | Transcription factor required for derepression of inositol-choline-regulated genes |