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Table 2 Genes identified as up-regulated response to antigen stimulation in previous studies with mycobacterial antigens.

From: Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birth

Genbank Symbol *Fold PPD *Fold BCG *BCG over PPD Cell type Stimulus Reference
NM_000600 IL-6 67.97 83.42 1.23 Mφ1, Mφ, DC M.tb, BCG Chaussabel et. al. 2003
Verrek et. al. 2006
Begum et. al. 2004
NM_000576 IL-1 β 17.34 15.10 0.87 Mφ1, Mφ, DC, Guinea-pig splenocytes M.tb, BCG, PPD Chaussabel et. al. 2003
Verrek et. al. 2006
Begum et. al. 2004
Khajoee et. al. 2006
Tree et. al. 2006
NM_001511 GRO-1, CXCL1 27.12 16.89 0.62 Mφ1, Mφ, DC M.tb, BCG Chaussabel et. al. 2003 Khajoee et. al. 2006
NM_002421 MMP1 7.21 17.18 2.38 Mφ1, Mφ, DC M.tb, BCG Chaussabel et. al. 2003
NM_002089 GRO-2, CXCL2, MIP-2A 19.24 24.10 1.25 Mφ1, Mφ, DC M.tb Chaussabel et. al. 2003
NM_002090 GRO-3, CXCL3 15.94 9.91 0.62 Mφ1 M.tb Chaussabel et. al. 2003
NM_000594 TNF-α 4.86 9.49 1.95 Mφ1, Mφ, DC M.tb, BCG Chaussabel et. al. 2003
Verrek et. al. 2006
Begum et. al. 2004
NM_000963 PTGS2, COX2 10.35 13.17 1.27 Mφ, DC M.tb Chaussabel et. al. 2003
NM_002984 MIP-1β, CCL4 4.19 5.47 1.31 Mφ1, Mφ, DC M.tb Chaussabel et. al. 2003
Verrek et. al. 2006 Cliff et al. 2004
NM_007115 TNFAIP6. 9.10 7.12 0.78 Mφ, DC M.tb, BCG Chaussabel et. al. 2003 Khajoee et. al. 2006
NM_000584 IL-8 3.62 3.60 0.99 Mφ1, Mφ, DC, Guinea-pig splenocytes, CD4+ M.tb, BCG, PPD Chaussabel et. al. 2003
Verrek et. al. 2006 Khajoee et. al. 2006
Tree et. al. 2006
Cliff et al. 2004
NM_139266 STAT-1 2.41 4.52 1.88 Mφ, DC
M.tb
PPD
Chaussabel et. al. 2003, Begum et. al. 2004
NM_015714 GOS-2 4.36 4.26 0.98 Mφ, DC M.tb Chaussabel et. al. 2003
NM_004184 WARS 1.52 2.29 1.51 Mφ, DC
Guinea-pig splenocytes
M.tb
PPD
Chaussabel et. al. 2003 Tree et. al. 2006
NM_000595 LTA 2.31 2.28 0.99 Mφ, DC M.tb Chaussabel et. al. 2003
NM_001955 EDN1 1.93 3.41 1.77 Mφ, DC M.tb Chaussabel et. al. 2003
NM_001565 IP-10, CXCL10 2.28 3.56 1.56 Mφ, DC M.tb Chaussabel et. al. 2003
NM_002462 MX1 1.26 1.59 1.26 Mφ, DC M.tb Chaussabel et. al. 2003
NM_002164 INDO 3.01 2.42 0.80 Mφ, DC   Chaussabel et. al. 2003
NM_002460 IRF4 1.56 1.89 1.21 Mφ, DC M.tb Chaussabel et. al. 2003
NM_002990 MDC, CCL22 3.53 3.12 0.88 Mφ1 M.tb Verrek et. al. 2006
NM_005746 PBEF 3.36 2.37 0.71 BCG Begum et. al. 2004
NM_002187 IL-12p40 1.98 2.66 1.35 BCG Begum et. al. 2004
NM_004591 CCL20, MIP3A 24.49 37.96 1.55 Mφ2 BCG Khajoee et. al. 2006
NM_000636 SOD2 4.25 3.61 0.85 Mφ1 BCG Khajoee et. al. 2006
NM_004049 BCL2A1 2.75 2.55 0.93 Mφ1
CD8+
BCG, M.tb Khajoee et. al. 2006
Cliff et. al. 2004
NM_002053 GBP1 2.31 5.25 2.28 Bovine PBMC PPD Meade et. al. 2006
NM_000758 GM-CSF 36.79 77.65 2.11 Guinea-pig splenocytes PPD Tree et. al. 2006
NM_000575 IL-1alpha 21.60 22.38 1.04 Guinea-pig splenocytes PPD Tree et. al. 2006
NM_003745 SOCS-1 1.65 2.37 1.44 CD8+ M.tb Cliff et al. 2004
NM_172219 CSF3, G-CSF 2.93 9.17 3.13 CD8+ M.tb Cliff et al. 2004
  1. Genes reported as differentially expressed in previous studies and also differentially expressed in this current study are listed. * Median fold change in normalised expression.