Figure 1

The average probeset expression values in the LCM microarrays plotted against the average in the bulk microarrays, for normal and cancer tissues. The selection thresholds for determining significantly varied expression are noted (white lines). Most variant probesets exhibited higher expression in the bulk microarrays versus the LCM microarrays, with 387 probesets in the normal tissue and 500 probesets in the cancer tissue displaying significantly different expression values in the LCM vs. bulk microarrays. The overlaid box-plots illustrate the distribution of variant probesets identified in the individual matched-case comparisons. No statistically significant differences in the number of altered probesets were found between normal lung tissue and lung adenocarcinoma.