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Figure 2 | BMC Medical Genomics

Figure 2

From: Impact of sample acquisition and linear amplification on gene expression profiling of lung adenocarcinoma: laser capture micro-dissection cell-sampling versus bulk tissue-sampling

Figure 2

Probesets with significant changes in expression level between bulk, LCM, and linear amplified bulk samples. There is a similar distribution of overlapping probesets between the bulk samples and either of the amplified samples (LCM or Linear Amplified Bulk). Between amplified samples, there are very few probesets with significant changes in expression level, suggesting most of the changes observed between bulk and LCM are a by-product of an amplification protocol bias. These observations were consistent in both (A) normal tissue samples, and (B) cancer tissue samples.

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BMC Medical Genomics

ISSN: 1755-8794

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