Table 5 Gene microarray data corresponding to detected tear proteins.
Name of gene corresponding to tear protein | Genbank Accession | No of fold change | p value |
|---|---|---|---|
A. Genes significantly regulated in pterygium | Â | Â | Â |
Prolactin-induced protein I | NM_002652 | 2.149 | 0.000213 |
S100A8 (Calgranulin A) | NM_002964 | 1.74 | 0.0000082 |
Defensin alpha A1 | U73945 | 1.506 | 0.0149 |
S100 A9 | NM_002965 | 1.442 | 0.00204 |
Hepatocellular carcinoma associated protein (PIGR) | NM_002644 | 1.371 | 0.0299 |
Vimentin | AI922599 | 1.278 | 0.0324 |
Beta-2 microglobulin | NM_004048 | 1.188 | 0.0378 |
Cathepsin G | NM_001911 | 1.141 | 0.00984 |
S100 A12 | NM_005621 | 1.122 | 0.0268 |
Clusterin (Apolipoprotein J) | AI982754 | 1.08 | 0.0287 |
Vitamin D binding protein | NM_000583 | 1.052 | 0.0437 |
Cystatin SN | NM_001898 | 0.946 | 0.0121 |
Histone 1b | NM_005322 | 0.941 | 0.00456 |
Orosomucoid 1 (alpha 1 acid glycoprotein) | NM_000607 | 0.94 | 0.0027 |
Anti-thrombin III | D29832 | 0.937 | 0.000451 |
Beta actin | X00351 | 0.888 | 0.0263 |
Proline rich Peptide | NM_025263 | 0.864 | 0.00355 |
Ribonuclease 4 | NM_002937 | 0.725 | 0.000675 |
Alpha-1-antitrypsin (SERPINA1) | NM_000295 | 0.72 | 0.0399 |
Ceruloplasmin (ferroxidase) | NM_000096 | 0.637 | 0.000375 |
Complement C3 | NM_000064 | 0.607 | 0.00443 |
Lipophilin C (SCGB2A1) | NM_002407 | 0.402 | 0.000045 |
B. Genes not significantly regulated in pterygium | Â | Â | Â |
IGHM protein | L23517 | 0.89 | 0.0511 |
Lipophilin A | NM_006552 | 0.955 | 0.073 |
Zn-alpha2-glycoprotein | D90427 | 1.223 | 0.0788 |
Apolipoprotein A-I | NM_000039 | 0.934 | 0.0874 |
Immunoglobulin kappa light | M63438 | 0.559 | 0.0878 |
Mucin 7 | L13283 | 1.023 | 0.0895 |
Lipocalin 1 | NM_002297 | 0.949 | 0.135 |
Alpha-fibrinogen | NM_021871 | 1.038 | 0.261 |
Transferrin | A1073407 | 0.97 | 0.319 |
Proline rich 4 (lacrimal) | NM_007244 | 0.959 | 0.32 |
Nasopharyngeal carcinoma associated proline rich protein 4 | NM_007244 | 0.959 | 0.32 |
Lactoferrin | NM_002343 | 1.068 | 0.366 |
Complement Factor-B | AF349679 | 1.048 | 0.386 |
Immunoglobulin J chain | AV733266 | 0.707 | 0.398 |
cystatin SA | NM_001322 | 0.977 | 0.415 |
Apolipoprotein A-IV | NM_000482 | 0.977 | 0.442 |
Transthyretin | AH62690 | 1.024 | 0.493 |
Lysozyme | NM_020426 | 0.982 | 0.527 |
Complement factor H | X04697 | 0.956 | 0.542 |
Annexin I | NM_000700 | 0.959 | 0.583 |
Secretary leukocyte protease inhibitor | NM_003064 | 0.944 | 0.592 |
Proline rich protein 5 | NM_012390 | 1.145 | 0.597 |
Coagulation factor H (thrombin) | NM_000506 | 0.979 | 0.6 |
Neutrophil elastase | NM_001972 | 0.99 | 0.68 |
Apolipoprotein H | NM_000042 | 1.013 | 0.691 |
Hemopexin | BC005395 | 1.013 | 0.7 |
Albumin | AF116645 | 1.007 | 0.8 |
Haptoglobin | NM_005143 | 1.005 | 0.836 |
Basic proline rich protein | X07882 | 1.004 | 0.905 |