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Table 2 Most significant GO functions in three GO classes.

From: Correlation of microRNA levels during hypoxia with predicted target mRNAs through genome-wide microarray analysis

Most significant GO Biological Processes
GO Term GO ID Changed Genes Total Genes in Class P-Value Fraction
Cholesterol biosynthesis GO:0006695 12 20 7.04E-09 0.600
Nuclear mRNA splicing, via spliceosome GO:0000398 29 110 9.77E-09 0.264
glycolysis GO:0006096 14 39 1.16E-07 0.359
Protein biosynthesis GO:0006412 38 247 8.00E-07 0.154
transport GO:0006810 50 415 8.94E-07 0.120
Protein metabolism GO:0019538 9 17 4.90E-06 0.529
Protein folding GO:0006457 28 174 5.59E-06 0.161
Ribosome biogenesis GO:0007046 6 14 3.22E-05 0.429
metabolism GO:0008152 39 316 9.36E-05 0.123
tRNA processing GO:0008033 8 33 5.32E-04 0.242
Regulation of the cyclin dependent protein kinase activity GO:0000079 8 34 9.72E-04 0.235
Amino acid biosynthesis GO:0008652 6 22 1.01E-03 0.273
Lipid metabolism GO:0006629 24 193 1.02E-03 0.124
Regulation of progression through cell cycle GO:0000074 27 200 1.14E-03 0.135
Cell cycle GO:0007049 41 338 1.64E-03 0.121
Regulation of translational initiation GO:0006446 7 22 1.88E-03 0.318
Most significant GO Molecular Function.
GO Term GO ID Changed Genes Total Genes in Class P-Value Fraction
Nucleotide binding GO:0000166 173 1405 6.92E-11 0.123
RNA binding GO:0003723 78 389 4.22E-10 0.201
Oxidoreductase activity GO:0016491 61 382 6.44E-10 0.160
ATP binding GO:0005524 123 1116 1.20E-09 0.110
Unfolded protein binding GO:0051082 28 143 2.68E-08 0.196
Protein binding GO:0005515 220 2514 1.77E-07 0.088
Transferase activity GO:0016740 101 958 1.86E-07 0.105
L-ascorbic acid binding GO:0031418 6 11 1.65E-05 0.545
Lyase activity GO:0016829 16 89 1.37E-04 0.180
binding GO:0005488 47 399 2.37E-04 0.118
ATP-dependent RNA helicase activity GO:0004004 7 18 4.61E-04 0.389
Isomerase activity GO:0016853 15 90 5.54E-04 0.167
Ligase activity GO:0016874 27 184 5.54E-04 0.147
Oxidoreductase activity GO:0016702 6 18 6.72E-04 0.333
NAD binding GO:0051287 8 24 7.05E-04 0.333
Catalytic activity GO:0003824 27 192 7.40E-04 0.141
Transporter activity GO:0005215 29 281 1.50E-03 0.103
Kinase activity GO:0016301 22 163 1.65E-03 0.135
tRNA binding GO:0000049 5 13 1.87E-03 0.385
Most significant GO Cellular Component
GO Term GO ID Changed genes Total genes in class P-value Fraction
cytoplasm GO:0005737 114 895 5.00E-10 0.127
nucleus GO:0005634 281 2999 5.00E-10 0.094
mitochondrion GO:0005739 70 528 1.01E-09 0.133
endoplasmic reticulum GO:0005783 49 405 2.47E-06 0.121
mitochondrial inner membrane presequence translocase complex GO:0005744 5 11 2.82E-04 0.455
soluble fraction GO:0005625 24 194 3.22E-04 0.124
nucleolus GO:0005730 12 59 1.09E-03 0.203
  1. The fraction reflects genes differentially expressed relative to the total number of genes in that class.