Table 2 Most significant GO functions in three GO classes.
Most significant GO Biological Processes | |||||
|---|---|---|---|---|---|
GO Term | GO ID | Changed Genes | Total Genes in Class | P-Value | Fraction |
Cholesterol biosynthesis | GO:0006695 | 12 | 20 | 7.04E-09 | 0.600 |
Nuclear mRNA splicing, via spliceosome | GO:0000398 | 29 | 110 | 9.77E-09 | 0.264 |
glycolysis | GO:0006096 | 14 | 39 | 1.16E-07 | 0.359 |
Protein biosynthesis | GO:0006412 | 38 | 247 | 8.00E-07 | 0.154 |
transport | GO:0006810 | 50 | 415 | 8.94E-07 | 0.120 |
Protein metabolism | GO:0019538 | 9 | 17 | 4.90E-06 | 0.529 |
Protein folding | GO:0006457 | 28 | 174 | 5.59E-06 | 0.161 |
Ribosome biogenesis | GO:0007046 | 6 | 14 | 3.22E-05 | 0.429 |
metabolism | GO:0008152 | 39 | 316 | 9.36E-05 | 0.123 |
tRNA processing | GO:0008033 | 8 | 33 | 5.32E-04 | 0.242 |
Regulation of the cyclin dependent protein kinase activity | GO:0000079 | 8 | 34 | 9.72E-04 | 0.235 |
Amino acid biosynthesis | GO:0008652 | 6 | 22 | 1.01E-03 | 0.273 |
Lipid metabolism | GO:0006629 | 24 | 193 | 1.02E-03 | 0.124 |
Regulation of progression through cell cycle | GO:0000074 | 27 | 200 | 1.14E-03 | 0.135 |
Cell cycle | GO:0007049 | 41 | 338 | 1.64E-03 | 0.121 |
Regulation of translational initiation | GO:0006446 | 7 | 22 | 1.88E-03 | 0.318 |
Most significant GO Molecular Function. | |||||
GO Term | GO ID | Changed Genes | Total Genes in Class | P-Value | Fraction |
Nucleotide binding | GO:0000166 | 173 | 1405 | 6.92E-11 | 0.123 |
RNA binding | GO:0003723 | 78 | 389 | 4.22E-10 | 0.201 |
Oxidoreductase activity | GO:0016491 | 61 | 382 | 6.44E-10 | 0.160 |
ATP binding | GO:0005524 | 123 | 1116 | 1.20E-09 | 0.110 |
Unfolded protein binding | GO:0051082 | 28 | 143 | 2.68E-08 | 0.196 |
Protein binding | GO:0005515 | 220 | 2514 | 1.77E-07 | 0.088 |
Transferase activity | GO:0016740 | 101 | 958 | 1.86E-07 | 0.105 |
L-ascorbic acid binding | GO:0031418 | 6 | 11 | 1.65E-05 | 0.545 |
Lyase activity | GO:0016829 | 16 | 89 | 1.37E-04 | 0.180 |
binding | GO:0005488 | 47 | 399 | 2.37E-04 | 0.118 |
ATP-dependent RNA helicase activity | GO:0004004 | 7 | 18 | 4.61E-04 | 0.389 |
Isomerase activity | GO:0016853 | 15 | 90 | 5.54E-04 | 0.167 |
Ligase activity | GO:0016874 | 27 | 184 | 5.54E-04 | 0.147 |
Oxidoreductase activity | GO:0016702 | 6 | 18 | 6.72E-04 | 0.333 |
NAD binding | GO:0051287 | 8 | 24 | 7.05E-04 | 0.333 |
Catalytic activity | GO:0003824 | 27 | 192 | 7.40E-04 | 0.141 |
Transporter activity | GO:0005215 | 29 | 281 | 1.50E-03 | 0.103 |
Kinase activity | GO:0016301 | 22 | 163 | 1.65E-03 | 0.135 |
tRNA binding | GO:0000049 | 5 | 13 | 1.87E-03 | 0.385 |
Most significant GO Cellular Component | |||||
GO Term | GO ID | Changed genes | Total genes in class | P-value | Fraction |
cytoplasm | GO:0005737 | 114 | 895 | 5.00E-10 | 0.127 |
nucleus | GO:0005634 | 281 | 2999 | 5.00E-10 | 0.094 |
mitochondrion | GO:0005739 | 70 | 528 | 1.01E-09 | 0.133 |
endoplasmic reticulum | GO:0005783 | 49 | 405 | 2.47E-06 | 0.121 |
mitochondrial inner membrane presequence translocase complex | GO:0005744 | 5 | 11 | 2.82E-04 | 0.455 |
soluble fraction | GO:0005625 | 24 | 194 | 3.22E-04 | 0.124 |
nucleolus | GO:0005730 | 12 | 59 | 1.09E-03 | 0.203 |