Figure 2

KGraph: Genetic Architecture of Log Leukoaraiosis. Using 8 regions, the KGraph shows the relationships between the SNPs, covariates, and outcome by displaying the results from tests of correlation, linkage disequilibrium, association and FDR/Replication/Cross-validation. The key at the bottom of the graphic shows the test criterion for each region and the colors associated with the test result. The region number key in the lower left corner shows the location of each region, and indicates whether the results in the region were assessed using FDR/Replication/Cross-validation (shaded regions). A black bar in the cell indicates that the association passed all three of these criteria. Region 1 displays the association between the SNPs and the covariates, region 2 displays the correlation between the covariates, and region 3 displays the linkage disequilibrium between the SNPs. Region 4 displays covariate association with leukoaraiosis, region 5 displays SNP association with leukoaraiosis, region 6 displays covariate-covariate interactions predicting leukoaraiosis, region 7 displays SNP-covariate interactions predicting leukoaraiosis, and region 8 displays SNP-SNP (epistatic) interactions predicting leukoaraiosis. Included on the KGraph are all of the covariates that were investigated in the study, SNPs that were involved in a single SNP or SNP-covariate association that passed all three filters, and SNPs that were involved in at least one of the 20 most predictive SNP-SNP interactions that passed all three filters.