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Table 4 Multivariable analysis to assess combined predictive ability of the best SNPs, covariates, and interactions

From: Complexity in the genetic architecture of leukoaraiosis in hypertensive sibships from the GENOA Study

Model

Adjusted R2 × 100

CV R2 × 100

1. Top Single SNPs

5.99

3.72

2. Top 4 SNP*Covariate Interactions

  

Full Model

7.88

4.53

Reduced Model

2.64

-0.06

Differencea

 

4.53

3. Top 4 SNP*SNP Interactions

  

Full Model

14.73

9.59

Reduced Model

6.12

2.27

Difference

 

7.32

4. Top 4 SNP*Covariate Interactions + Top 4 SNP*SNP Interactions

  

Full Model

19.18

11.83

Reduced Model

7.18

1.3

Difference

 

10.8

5. Single SNPs + Top 4 SNP*Covariate Interactions + Top 4 SNP*SNP Interactions

  

Full Model

21.32

11.6

Reduced Model

9.99

2.16

Difference

 

9.34

  1. a In calculating the difference in CV R2 between full and reduced models, the CV R2 of the reduced model was considered to be zero if it had a negative value.
  2. For all associations, the outcome was leukoaraiosis volume transformed using the natural logarithm and adjusted for age, sex, and total brain volume.
  3. 1. Model:F3_rs3917643 +KITLG_rs995029 +CAPN10_rs7571442 + MMP2_rs9928731
  4. 2. Full model: KITLG_rs1492347*Log Homocysteine + ITGB3_rs3851806*Height +TGFB3_rs2284791*Log CCRP + TGFB3_rs2284791*Physical Activity; Reduced model:KITLG_rs1492347 + Log Homocysteine + ITGB3_rs3851806 + Height + TGFB3_rs2284791 + Log CCRP + Physical Activity
  5. 3. Full model:RHAG_rs11759060*GLS_rs1921913 + F8_rs7053448*MPO_rs34704261 + SLC20A1_rs10758*IL22RA1_rs12093987 + KITLG_rs995029*TLR4_rs1927911; Reduced model: RHAG_rs11759060 + GLS_rs1921913 + F8_rs7053448 + MPO_rs34704261 + SLC20A1_rs10758 + IL22RA1_rs12093987 + KITLG_rs995029 + TLR4_rs1927911
  6. 4. Full model: KITLG_rs1492347*Log Homocysteine +ITGB3_rs3851806*Height + TGFB3_rs2284791*Log CCRP +TGFB3_rs2284791*Physical Activity + RHAG_rs11759060*GLS_rs1921913 + F8_rs7053448*MPO_rs34704261 + SLC20A1_rs10758*IL22RA1_rs12093987 + KITLG_rs995029*TLR4_rs1927911; Reduced model: KITLG_rs1492347 + Log Homocysteine + ITGB3_rs3851806 + Height + TGFB3_rs2284791 + Log CCRP + Physical Activity + RHAG_rs11759060 + GLS_rs1921913 + F8_rs7053448 + MPO_rs34704261 + SLC20A1_rs10758 + IL22RA1_rs12093987 + KITLG_rs995029 + TLR4_rs1927911
  7. 5. Full model: F3_rs3917643 +KITLG_rs995029 +CAPN10_rs7571442 + MMP2_rs9928731 +KITLG_rs1492347*Log Homocysteine + ITGB3_rs3851806*Height + TGFB3_rs2284791*Log CCRP + TGFB3_rs2284791*Physical Activity + RHAG_rs11759060*GLS_rs1921913 + F8_rs7053448*MPO_rs34704261 + SLC20A1_rs10758*IL22RA1_rs12093987 + KITLG_rs995029*TLR4_rs1927911; Reduced model: F3_rs3917643 +KITLG_rs995029 +CAPN10_rs7571442+ MMP2_rs9928731+KITLG_rs1492347 + Log Homocysteine + ITGB3_rs3851806 + Height + TGFB3_rs2284791 + Log CCRP + Physical Activity + RHAG_rs11759060 + GLS_rs1921913 + F8_rs7053448 + MPO_rs34704261 + SLC20A1_rs10758 + IL22RA1_rs12093987 + TLR4_rs1927911
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BMC Medical Genomics

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