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Figure 1 | BMC Medical Genomics

Figure 1

From: Tamoxifen-elicited uterotrophy: cross-species and cross-ligand analysis of the gene expression program

Figure 1

Dose Response Uterine Wet Weights (UWW). UWW was measured across several EE and TAM doses in the mouse and rat. A plot of the fold change increase in wet weight is plotted. A dose response curve was fit to the data (GraphPad 4.0) to estimate EC50 values. 100 μg/kg b.w. approximates the maximum response in all four cases and was used in subsequent time course studies. ED50 values were comparable between ligands in the rat while exhibiting only a two fold difference in the mouse, indicating conservation of sensitivity to EE and TAM.

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BMC Medical Genomics

ISSN: 1755-8794

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