Apoptosis induced by drugs. Panel A: Kinetics and extent of apoptosis induction after exposure of K562 cells to 1 μM Imatinib (as determined through the annexin test and FACS analysis). Panel B: Kinetics and extent of apoptosis induction after exposure of SH-SY5Y cells to 3 μM of Fenretinide. Panel C: Modification of the AM transcriptome in K562 and SH-SY5Y after drug treatment (see Materials and Methods). Panel D: Modification of the expression of AM cancer candidates (i.e., previously identified as potentially involved in the pathogenesis of specific cancers) as opposed to that of other AM genes, presumed not to be involved in the process (i.e., not candidates) during apoptosis induction in K562 and SH-SY5Y.