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Table 1 Pro AM core genes

From: The apoptotic machinery as a biological complex system: analysis of its omics and evolution, identification of candidate genes for fourteen major types of cancer, and experimental validation in CML and neuroblastoma

AM GENES FAMILY PATHWAY FUNCTION
APAF1   p53 Pathway, Apoptosome PRO
BAD   Apoptotic Mitochondrial Pathway PRO
BAK1 BCL-2 RELATED Apoptotic Mitochondrial Pathway PRO
BAX BCL-2 RELATED Apoptotic Mitochondrial Pathway, p53 Pathway PRO
BCL2L1 BCL-2 RELATED Apoptotic Mitochondrial Pathway PRO*
BID BCL-2 RELATED Apoptotic Mitochondrial Pathway PRO
CARD12 NALP Caspase Cascade PRO
CARD4 NALP Caspase Cascade PRO
CARD8 NALP Caspase Cascade PRO
CASP10 CASPASE Caspase Cascade PRO
CASP3 CASPASE Caspase Cascade PRO
CASP6 CASPASE Caspase Cascade PRO
CASP7 CASPASE Caspase Cascade PRO
CASP8 CASPASE Caspase Cascade PRO
CASP9 CASPASE Caspase Cascade, Apoptosome PRO
CFLAR CASPASE FAS Signaling Pathway PRO*
CHUK SER/THR KINASE AKT Signaling Pathway, Induction of Apoptosis through DR3 and DR4/5 Death Receptors PRO
CYCS   Caspase Cascade, Apoptosome PRO
DAP   IFN-Gamma-Induced Cell Death PRO
DAP3   IFN-Gamma-Induced Cell Death, FAS Signaling Pathway, SODD/TNFR1 Signaling Pathway PRO
DAPK1   IFN-Gamma-Induced Cell Death PRO
DAXX   FAS Signaling Pathway PRO
DFFA   Apoptotic DNA Fragmentation and Tissue Homeostasis PRO
DFFB   Apoptotic DNA Fragmentation and Tissue Homeostasis PRO
FADD   FAS Signaling Pathway PRO
FAS TNF RECEPTOR FAS Signaling Pathway PRO*
FASLG TNF FAS Signaling Pathway PRO
HRK   Apoptotic Mitochondrial Pathway PRO
IL1A INTERLEUKIN 1 CYTOKINE NF-kB Signaling Pathway PRO*
IL1R1 INTERLEUKIN 1 RECEPTOR NF-kB Signaling Pathway PRO*
MCL1 BCL-2 RELATED Apoptotic Mitochondrial Pathway PRO*
NALP1 NALP FAS Signaling Pathway PRO
NFKBIA   AKT Signaling Pathway, Induction of Apoptosis through DR3 and DR4/5 Death Receptors, NF-kB Signaling Pathway PRO
RIPK1 SER/THR KINASE NF-kB Signaling Pathway, Induction of Apoptosis through DR3 and DR4/5 Death Receptors PRO
TNF TNF SODD/TNFR1 Signaling Pathway PRO*
TNFRSF10A TNF RECEPTOR Induction of Apoptosis through DR3 and DR4/5 Death Receptors, Natural Killer Cell Mediated Cytotoxicity PRO
TNFRSF10B TNF RECEPTOR p53 Pathway, Natural Killer Cell Mediated Cytotoxicity PRO
TNFRSF1A TNF RECEPTOR SODD/TNFR1 Signaling Pathway PRO
TNFSF10 TNF Induction of Apoptosis through DR3 and DR4/5 Death Receptors PRO
TP53 TP53-RELATED Apoptotic Signaling in Response to DNA Damage, ATM Signaling Pathway, PRO
TRADD   Induction of Apoptosis through DR3 and DR4/5 Death Receptors PRO
TRAF2 TRAF Induction of Apoptosis through DR3 and DR4/5 Death Receptors PRO*
  1. The symbol "*" means involvement also in anti-apoptotic functions.