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Table 1 Pro AM core genes

From: The apoptotic machinery as a biological complex system: analysis of its omics and evolution, identification of candidate genes for fourteen major types of cancer, and experimental validation in CML and neuroblastoma

AM GENES

FAMILY

PATHWAY

FUNCTION

APAF1

 

p53 Pathway, Apoptosome

PRO

BAD

 

Apoptotic Mitochondrial Pathway

PRO

BAK1

BCL-2 RELATED

Apoptotic Mitochondrial Pathway

PRO

BAX

BCL-2 RELATED

Apoptotic Mitochondrial Pathway, p53 Pathway

PRO

BCL2L1

BCL-2 RELATED

Apoptotic Mitochondrial Pathway

PRO*

BID

BCL-2 RELATED

Apoptotic Mitochondrial Pathway

PRO

CARD12

NALP

Caspase Cascade

PRO

CARD4

NALP

Caspase Cascade

PRO

CARD8

NALP

Caspase Cascade

PRO

CASP10

CASPASE

Caspase Cascade

PRO

CASP3

CASPASE

Caspase Cascade

PRO

CASP6

CASPASE

Caspase Cascade

PRO

CASP7

CASPASE

Caspase Cascade

PRO

CASP8

CASPASE

Caspase Cascade

PRO

CASP9

CASPASE

Caspase Cascade, Apoptosome

PRO

CFLAR

CASPASE

FAS Signaling Pathway

PRO*

CHUK

SER/THR KINASE

AKT Signaling Pathway, Induction of Apoptosis through DR3 and DR4/5 Death Receptors

PRO

CYCS

 

Caspase Cascade, Apoptosome

PRO

DAP

 

IFN-Gamma-Induced Cell Death

PRO

DAP3

 

IFN-Gamma-Induced Cell Death, FAS Signaling Pathway, SODD/TNFR1 Signaling Pathway

PRO

DAPK1

 

IFN-Gamma-Induced Cell Death

PRO

DAXX

 

FAS Signaling Pathway

PRO

DFFA

 

Apoptotic DNA Fragmentation and Tissue Homeostasis

PRO

DFFB

 

Apoptotic DNA Fragmentation and Tissue Homeostasis

PRO

FADD

 

FAS Signaling Pathway

PRO

FAS

TNF RECEPTOR

FAS Signaling Pathway

PRO*

FASLG

TNF

FAS Signaling Pathway

PRO

HRK

 

Apoptotic Mitochondrial Pathway

PRO

IL1A

INTERLEUKIN 1 CYTOKINE

NF-kB Signaling Pathway

PRO*

IL1R1

INTERLEUKIN 1 RECEPTOR

NF-kB Signaling Pathway

PRO*

MCL1

BCL-2 RELATED

Apoptotic Mitochondrial Pathway

PRO*

NALP1

NALP

FAS Signaling Pathway

PRO

NFKBIA

 

AKT Signaling Pathway, Induction of Apoptosis through DR3 and DR4/5 Death Receptors, NF-kB Signaling Pathway

PRO

RIPK1

SER/THR KINASE

NF-kB Signaling Pathway, Induction of Apoptosis through DR3 and DR4/5 Death Receptors

PRO

TNF

TNF

SODD/TNFR1 Signaling Pathway

PRO*

TNFRSF10A

TNF RECEPTOR

Induction of Apoptosis through DR3 and DR4/5 Death Receptors, Natural Killer Cell Mediated Cytotoxicity

PRO

TNFRSF10B

TNF RECEPTOR

p53 Pathway, Natural Killer Cell Mediated Cytotoxicity

PRO

TNFRSF1A

TNF RECEPTOR

SODD/TNFR1 Signaling Pathway

PRO

TNFSF10

TNF

Induction of Apoptosis through DR3 and DR4/5 Death Receptors

PRO

TP53

TP53-RELATED

Apoptotic Signaling in Response to DNA Damage, ATM Signaling Pathway,

PRO

TRADD

 

Induction of Apoptosis through DR3 and DR4/5 Death Receptors

PRO

TRAF2

TRAF

Induction of Apoptosis through DR3 and DR4/5 Death Receptors

PRO*

  1. The symbol "*" means involvement also in anti-apoptotic functions.