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Table 2 Anti AM core genes

From: The apoptotic machinery as a biological complex system: analysis of its omics and evolution, identification of candidate genes for fourteen major types of cancer, and experimental validation in CML and neuroblastoma

AM GENES FAMILY PATHWAY FUNCTION
AKT1 SER/THR KINASE FAS Sgnaling Pathway ANTI
BAG1 BCL2-ASSOCIATED ATHANOGENE SODD/TNFR1 Signaling Pathway ANTI
BAG3 BCL2-ASSOCIATED ATHANOGENE SODD/TNFR1 Signaling Pathway ANTI
BAG4 BCL2-ASSOCIATED ATHANOGENE SODD/TNFR1 Signaling Pathway ANTI
BCL2 BCL-2 RELATED Apoptotic Mitochondrial Pathway, p53 Pathway ANTI
BCL2L1 BCL-2 RELATED Apoptotic Mitochondrial Pathway ANTI*
BIRC2 BIRC Apoptotic Mitochondrial Pathway, Caspase Cascade ANTI
BIRC3 BIRC Apoptotic Mitochondrial Pathway, Caspase Cascade, SODD/TNFR1 Signaling Pathway ANTI
BIRC4 BIRC Apoptotic Mitochondrial Pathway, Caspase Cascade, B Cell Survival Pathway ANTI
BIRC5 BIRC B Cell Survival Pathway ANTI
CFLAR CASPASE FAS Signaling Pathway ANTI*
FAS TNF RECEPTOR FAS Signaling Pathway ANTI*
IL1A INTERLEUKIN 1 CYTOKINE NF-kB Signaling Pathway ANTI*
IL1R1 INTERLEUKIN 1 RECEPTOR NF-kB Signaling Pathway ANTI*
MAP3K14 SER/THR KINASE NF-kB Signaling Pathway, Induction of Apoptosis through DR3 and DR4/5 Death Receptors ANTI
MCL1 BCL-2 RELATED Apoptotic Mitochondrial Pathway ANTI*
MYD88   NF-kB Signaling Pathway ANTI
NFKB1   AKT Signaling Pathway, Induction of Apoptosis through DR3 and DR4/5 Death Receptors, NF-kB Signaling Pathway ANTI
NFKB2   AKT Signaling Pathway, Induction of Apoptosis through DR3 and DR4/5 Death Receptors, NF-kB Signaling Pathway ANTI
RELA   NF-kB Signaling Pathway ANTI
TNF TNF SODD/TNFR1 Signaling Pathway ANTI*
TNFRSF10C TNF RECEPTOR Natural Killer Cell Mediated Cytotoxicity ANTI
TNFRSF10D TNF RECEPTOR Natural Killer Cell Mediated Cytotoxicity ANTI
TRAF2 TRAF Induction of Apoptosis through DR3 and DR4/5 Death Receptors ANTI*
  1. The symbol "*" means involvement also in pro-apoptotic functions.