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Table 5 Transcriptome and proteome alterations of AM targets of MIRs

From: The apoptotic machinery as a biological complex system: analysis of its omics and evolution, identification of candidate genes for fourteen major types of cancer, and experimental validation in CML and neuroblastoma

GENE mRNA PROTEIN MIRs
BCL2 Up regulated in LUNG Up regulated in LUNG MIR15A, MIR16-1, MIR16-2, MIR34A down regulated in LUNG
CUL3 Up regulated in KIDNEY, PROSTATE Up regulated in KIDNEY, PROSTATE MIR22, MIR23A, MIR23B, MIR218-1, MIR218-2 MIR301 down regulated in KIDNEY; MIR22, MIR23A, MIR181A, MIR181C down regulated in PROSTATE
DFFB Normal in KIDNEY Up regulated in KIDNEY MIR124A-1, MIR124A-2, MIR124A-3 down regulated in KIDNEY
HTATIP Normal in KIDNEY Up regulated in KIDNEY MIR124A-1, MIR124A-2, MIR124A-3 down regulated in KIDNEY
IL1A Up regulated in LUNG; normal in PROSTATE Up regulated in LUNG; normal in PROSTATE MIR30B down regulated in LUNG and PROSTATE; MIR30D down regulated in LUNG
IRF1 Normal in LUNG, KIDNEY, PANCREAS Up regulated in LUNG, KIDNEY, PANCREAS MIR130A, MIR130B down regulated in LUNG, KIDNEY, PANCREAS; MIR23A down regulated in LUNG, KIDNEY
NGFR Normal in KIDNEY Up regulated in KIDNEY MIR7-1, MIR7-2, MIR7-3, MIR128A, MIR128B down regulated in KIDNEY
PDCD4 Down regulated in LUNG Up regulated in LUNG MIR15B, MIR16, MIR145, MIR195 down regulated in LUNG
RB1 Normal in KIDNEY Up regulated in KIDNEY MIR98, MIRLET7G down regulated in KIDNEY
RELA Normal in KIDNEY Up regulated in KIDNEY MIR124A-1, MIR124A-2, MIR124A-3 down regulated in KIDNEY
STAT3 Normal in KIDNEY Up regulated in KIDNEY MIR106 down regulated in KIDNEY
TP73L Down regulated in LUNG; normal in PANCREAS Up regulated in LUNG, PANCREAS MIR92 down regulated in LUNG, PANCREAS