The apoptotic machinery as a biological complex system: analysis of its omics and evolution, identification of candidate genes for fourteen major types of cancer, and experimental validation in CML and neuroblastoma

Table 6 MIR genes localized in rearranged genome regions and transcriptionally altered

Genome/Transcriptome	COLON	KIDNEY	LUNG	PANCREAS	PROSTATE
GAIN/UP				MIR10A
GAIN/DOWN			MIR133A2, MIR1-1	MIR1-1*
LOSS/DOWN	MIR1-2, MIR133A1, MIR30C-1	MIRLET7G, MIR128B	MIRLET7F1, MIRLET7G, MIRLET7D, MIR101-2, MIR10A, MIR128B, MIR143, MIR152, MIR15A, MIR15B, MIR16-1, MIR195, MIR199B, MIR19A, MIR19B1, MIR218-1, MIR218-2, MIR23B, MIR26A-1, MIR29C, MIR30B, MIR30D, MIR320, MIR34A, MIR34B	MIR130B, MIR141, MIR182, MIR19A, MIR19B1, MIR19B2, MIR200C, MIR222, MIR92A1, MIR92A2	MIR15A, MIR16-1, MIR19A, MIR19B1

The symbol * indicates those mature MIRs that could be encoded by different pre-MIR genes, localized in different genomic positions.

ISSN: 1755-8794