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Figure 4 | BMC Medical Genomics

Figure 4

From: High-resolution analysis of copy number alterations and associated expression changes in ovarian tumors

Figure 4

Chromosome 3 Amplifications and Associated Expression Changes. a) GISTIC Q-values for gain on chromosome 3, plotted as in Fig. 2. b) Close-up of the region of panel "a" indicated by vertical, red lines. The locations of all genes associated with a RefSeq transcript or Affymetrix probeset are indicated in red. c) Close-up of the region of panel "a" indicated by vertical, blue lines. The locations of all genes associated with a RefSeq transcript or an Affymetrix probeset are indicated in red. d) Expression ratios for genes in the genome region depicted in panel "b" and represented on the U133A and B arrays. The probeset with the highest variance in cancer samples was selected for each gene. Red bars indicate the log2 ratio of the mean value in tumor samples with copy gain of this gene and the mean value in tumor samples without gain of this gene. Orange bars represent the log2 ratio of the mean value in tumor samples with copy gain of this gene and the mean expression level in the normal samples. e) Expression ratios for genes in the genome region depicted in panel "c", plotted as in panel "d".

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