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Table 1 Metabolic pathways activation revealed by gene expression data from glaucomatous ONHAs

From: Network analysis of human glaucomatous optic nerve head astrocytes

      Metabolic pathway maps
Enzyme EC # Gene gene ID fold change
(combined set)
common protein name BAB RB CM VDP LB SMB AT
1.1.1.1. ADH1A 124 11.7 Alcohol dehydrogenase 1A +   +   +   
  ADH1B 125 9.7 Alcohol dehydrogenase 1B +   +   +   
  ADh1C 126 5.6 Alcohol dehydrogenase 1C +   +   +   
1.2.1.3. ALDH1A2 8854 2.2 Aldehyde dehydrogenase(NAD+) +     + +  
  ALDH1A3 220 5.1 Aldehyde dehydrogenase 1A3      + +  
  ALDH3A2 224 2.6 Aldehyde dehydrogenase 3A2 +     + +  
1.2.1.5 ALDH1A3 220 5.1 retylaldehyde dehydrogenase 1A3   +      
1.3.1.20 AKR1C1 1645 20.1 aldo-keto reductase 1C1 +       
1.14.14.1 CYP2D6 1565 2.3 cytochrome P450 family 2D6   + +   +   
  CYP2C9 1559 2.3 cytochrome P450 2C9   + +   +   +
  CYP1A1 1543 2 cytochrome P450 family IA   + +   +   +
  CYP3A4 1576 1.8 cytochrome P450 family IIIA4   + +    + +
  CYP7A1 1581 2.9 cytochrome P450 family 7A1 +       
  CYP27A1 1593 2.4 cytochrome P450C 27/25 +    +    
  CYP27B1 1594 1.6 calcidiol 1-monooxygenase     +    
2.1.1.- LCMT2 9836 2.3 leucine carboxyl methyltransferase 2       +  
6.3.2.- MID1 4281 3.5 midkine1       +  
  1. Abbreviations: BAB Bile acid biosynthesis; RBRetinol biosynthesis; CMCatecholamine metabolism; VDPVitamin D3 c23 and c24 pathways; LBLeukotrien 4 biosynthesis; SMBSerotonin-melatonin biosynthesis; ATAndrostenedion testosterone metabolism