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Table 1 Metabolic pathways activation revealed by gene expression data from glaucomatous ONHAs

From: Network analysis of human glaucomatous optic nerve head astrocytes

     

Metabolic pathway maps

Enzyme EC #

Gene

gene ID

fold change

(combined set)

common protein name

BAB

RB

CM

VDP

LB

SMB

AT

1.1.1.1.

ADH1A

124

11.7

Alcohol dehydrogenase 1A

+

 

+

 

+

  
 

ADH1B

125

9.7

Alcohol dehydrogenase 1B

+

 

+

 

+

  
 

ADh1C

126

5.6

Alcohol dehydrogenase 1C

+

 

+

 

+

  

1.2.1.3.

ALDH1A2

8854

2.2

Aldehyde dehydrogenase(NAD+)

+

   

+

+

 
 

ALDH1A3

220

5.1

Aldehyde dehydrogenase 1A3

    

+

+

 
 

ALDH3A2

224

2.6

Aldehyde dehydrogenase 3A2

+

   

+

+

 

1.2.1.5

ALDH1A3

220

5.1

retylaldehyde dehydrogenase 1A3

 

+

     

1.3.1.20

AKR1C1

1645

20.1

aldo-keto reductase 1C1

+

      

1.14.14.1

CYP2D6

1565

2.3

cytochrome P450 family 2D6

 

+

+

 

+

  
 

CYP2C9

1559

2.3

cytochrome P450 2C9

 

+

+

 

+

 

+

 

CYP1A1

1543

2

cytochrome P450 family IA

 

+

+

 

+

 

+

 

CYP3A4

1576

1.8

cytochrome P450 family IIIA4

 

+

+

  

+

+

 

CYP7A1

1581

2.9

cytochrome P450 family 7A1

+

      
 

CYP27A1

1593

2.4

cytochrome P450C 27/25

+

  

+

   
 

CYP27B1

1594

1.6

calcidiol 1-monooxygenase

   

+

   

2.1.1.-

LCMT2

9836

2.3

leucine carboxyl methyltransferase 2

     

+

 

6.3.2.-

MID1

4281

3.5

midkine1

     

+

 
  1. Abbreviations: BAB Bile acid biosynthesis; RB – Retinol biosynthesis; CM – Catecholamine metabolism; VDP – Vitamin D3 c23 and c24 pathways; LB – Leukotrien 4 biosynthesis; SMB – Serotonin-melatonin biosynthesis; AT – Androstenedion testosterone metabolism