Table 2 Distribution of Gene Ontology (GO) processes for the largest Direct Interactions (DI) network of genes up-regulated in the combined data set
From: Network analysis of human glaucomatous optic nerve head astrocytes
GO process | number of DE genes | # genes in a pathway | p-value |
|---|---|---|---|
upregulation, 196 nodes | |||
Cellular physiological process | 16 | 114 | 2.83e-11 |
Inflammatory response | 23 | 269 | 4.26e-11 |
Regulation of transcription, DNA-dependent | 51 | 1401 | 7.77e-09 |
Cell-cell signaling | 23 | 351 | 7.89e-09 |
Llipid metabolism | 17 | 197 | 1.44e-08 |
Alcohol metabolism | 5 | 7 | 1.92e-08 |
Transcription | 45 | 1182 | 1.97e-08 |
Positive regulation of cell proliferation | 17 | 215 | 5.28e-08 |
Signal transduction | 50 | 1493 | 1.65e-07 |
Cytokine and chemokine signaling | 5 | 96 | 2.07e-07 |
downregulation, 50 nodes | |||
Cell-cell signaling | 17 | 351 | 2.76E-13 |
Regulation of sodium ion transport | 4 | 4 | 4.39E-10 |
Norepinephrine-epinephrine regulation of blood pressure | 4 | 4 | 4.39E-10 |
Signal transduction | 26 | 1493 | 7.02E-10 |
immune response | 15 | 460 | 2.20E-09 |
Positive regulation of bone mineralization | 4 | 6 | 6.54E-09 |
Transmembrane receptor protein tyrosine kinase activation | 4 | 6 | 6.54E-09 |
Heat generation | 4 | 6 | 6.54E-09 |
Negative regulation of smooth muscle contraction | 4 | 6 | 6.54E-09 |
Norepinephrine-epinephrine vasodilation during regulation of blood pressure | 4 | 6 | 6.54E-09 |