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Table 2 Distribution of Gene Ontology (GO) processes for the largest Direct Interactions (DI) network of genes up-regulated in the combined data set

From: Network analysis of human glaucomatous optic nerve head astrocytes

GO process number of DE genes # genes in a pathway p-value
upregulation, 196 nodes
Cellular physiological process 16 114 2.83e-11
Inflammatory response 23 269 4.26e-11
Regulation of transcription, DNA-dependent 51 1401 7.77e-09
Cell-cell signaling 23 351 7.89e-09
Llipid metabolism 17 197 1.44e-08
Alcohol metabolism 5 7 1.92e-08
Transcription 45 1182 1.97e-08
Positive regulation of cell proliferation 17 215 5.28e-08
Signal transduction 50 1493 1.65e-07
Cytokine and chemokine signaling 5 96 2.07e-07
downregulation, 50 nodes
Cell-cell signaling 17 351 2.76E-13
Regulation of sodium ion transport 4 4 4.39E-10
Norepinephrine-epinephrine regulation of blood pressure 4 4 4.39E-10
Signal transduction 26 1493 7.02E-10
immune response 15 460 2.20E-09
Positive regulation of bone mineralization 4 6 6.54E-09
Transmembrane receptor protein tyrosine kinase activation 4 6 6.54E-09
Heat generation 4 6 6.54E-09
Negative regulation of smooth muscle contraction 4 6 6.54E-09
Norepinephrine-epinephrine vasodilation during regulation of blood pressure 4 6 6.54E-09