Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 5 Regulation of activated genes by transcription factors in the DI network

From: Network analysis of human glaucomatous optic nerve head astrocytes

  SP1 VDR AP-1 NF-κB AR
Upstream regulation MAPK13 MYB* AR AR CASP1
  NFATC1 HR EGR2 BST2 PIN1
  PRL IGF1 ELK4 STAT5* NFKB2
  PGR PTH MAPK13*   REL
  SAT PRL PTH   RAD9A
  STAT5 SP1 SP1   SVIL
  WT1 WT1 STAT5*   TCF21
     VDR*   VDR*
Down-stream targets ADH1A GPRC5A ALPL* ALPL* AR SOD2
  ADH1B ICAM1 APOD ADH1A* AKR1C1 AP-I/JUND
  ADH1C ID1 AR ADH1B* AQP9 AQP9
  ALDH1A1 IGF2 CD14* ADH1C* CEBPD * IGF1
  ALDH1A2 ITGA2 CRABP2 AKR1C1 CCL17 REL
  ALDH1A3 ITGB3 CD40L CYP27B1 * CD40L SAT *
  ALDH3A2 KIT CYP3A4 ICAM1* CLU  
  ALPL MMP2 CYP27B1 * CLU CDO1  
  ANGPT2 MPO CYP2C9 CRYZ CDN1A  
  ASS MYB * IGF1 EGR2 CYP27B1*  
  ATM OPRM1 IGF2* ELK4 GATA3  
  BCKDHB PLAT GDF8 GCLC CXCL1*  
  CEBPD POLE2 GATA3 GPRC5A CXCL3  
  CD14 PTGES HLA-DQA2 ID2 ICAM1*  
  CD43 PTHLH ID1 IL13RA2 GCLC  
  CES1 PURA IL11 IL8 IL13RA2  
  CHI3L1 SLC4A3 MAF ITGA2* IL8  
  CXCL1 SLC6A3 IL8 MMP8 HLA-DQA2  
  CYP27B1 SOD2 MYB MYB * MYB *  
  CYP3A7 SPP1 MYOD PDYN NCAM1  
  FBLN1 STAT5 NRP1 PGR* SPP1*  
  FBLN2 VDR PTGDS PRL* PGES*  
  FOS   PTH* TNFAIP6 SOD2*  
  HNF4A   PTHLH* VCAM1 VCAM1  
  GYPB   RHAG   WNT2B  
    SH3BP5   CXCL2  
    SLC22A3    
    SPP1*    
    VIL1    
  1. *Co-regulated by SP1
  2. Co-regulated by NF- κ B & AP-1 & VDR
  3. Co-regulated by NF- κ B & AP-1