Comparison of combined HHP and HHE. HHP and HHE are combined across all HIV-1 proteins. HHP performance is compared when restricting it to genes in HPRD, KEGG, and KEGG pathways enriched in HHP (p-value < .01, see Methods). The lower table compares HHE, HHP, and predictions from three siRNA screens. The darkened diagonal holds the sizes of all sets. The overlap between sets is below the diagonal, while p-values for these overlaps are above (see Methods).