Functional profiling. Example enrichment plots are shown for categories identified using GSEA as significantly enriched in either the (a) positively or (b) negatively correlated genes. Black bars represent the position of members of the category in the ranked list, together with the running enrichment score (plotted in green). The leading edge is defined as those genes in the gene set that appear in the ranked list at, or before, the point where the enrichment score reaches its maximum deviation from zero and can be interpreted as the core of a gene set that accounts for the enrichment signal. Examples shown are (a) oxidative phosphorylation (GO:006119) q = 0.000 (b) neuron differentiation (GO:030182) q = 0.143.