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Table 1 Functional profiling, positively correlated genes

From: Gene expression in the prefrontal cortex during adolescence: implications for the onset of schizophrenia

Functional group Gene set name No. of related sets No of members in gene set
(range)
FDR qvalue
(range)
Vesicle trafficking Membrane fusion 2 27–52 0.022–0.026
  Vesicle transport 9 16–348 0.002–0.149
  Vesicle docking during exocytosis 1 21 0.141
Transcription/translation Ribosome function 4 69–89 0.042–0.179
  mRNA processing 5 157–452 0.056–0.166
  Transcription from RNA pol III promoter 1 25 0.089
  mRNA catabolism 2 17–23 0.027–0.125
  translation 3 30–157 0.012–0.062
Protein transport/metabolism Protein transport 9 17–294 0.012–0.129
  Ubiquination/proteolysis 11 133–448 0.013–0.024
  Protein folding 1 195 0.003
  Carboxylic acid metabolism 7 17–410 0.087–0.195
  Aspartate family amino acid metabolism 1 18 0.016
  Amine metabolism 2 55–57 0.142–0.152
Electron transport chain Coenzyme metabolism 4 85–159 0.007–0.029
  Nucleotide metabolism 16 53–178 0.014–0.126
  ATP metabolism 9 36–490 0.012–0.192
  Oxidative phosphorylation 4 21–63 <0.001
  Electron transport 1 289 0.022
  Mitochondrial membrane 2 19–21 0.027–0.149
Glycolysis Aerobic respiration 7 22–32 0.005–0.016
  Glucose metabolism 13 20–138 0.005–0.079
Oxidative stress Response to oxidative stress 2 44–63 0.069–0.164
  Peroxisome organization and biogenesis 1 17 0.164
Cell cycle Mitotic cell cycle 5 17–60 0.077–0.144
  Induction of apoptosis by intracellular signals 1 20 0.067
Lipid metabolism Sphingomyelin synthesis 3 17–41 0.035–0.187
  Lipid modification 2 15–19 0.032–0.041
  Phospholipid metabolism 6 54–427 0.012–0.054
  Lipoprotein metabolism 3 29–42 0.027–0.069
  Glycerolipid metabolism 6 19–39 0.013–0.180
Others Iron compound metabolism 6 15–52 0.002–0.053
  Autophagy 1 16 0.062
  Polysaccharide biosynthesis 1 18 0.120
  Biopolymer biosynthesis 1 18 0.128
  Telomere maintenance 1 21 0.132
  Respiratory gaseous exchange 1 17 0.188
  Regulation of Wnt receptor signalling 1 15 0.188
  Vitamin metabolism 1 48 0.188
  1. Functional gene sets are shown which show enrichment in the list of genes positively correlated with a template showing peak expression in the 15–25 age range. Related gene sets as defined by leading edge analysis are grouped together in column 2 and the range of q values for these gene sets is indicated. Gene sets/groups of gene sets which are functionally associated but are composed of non-overlapping genes in the leading edge are indicated by headings in column 1. A full detailed list of significant gene sets can be found in Additional File 3.