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BMC Medical Genomics
Table 1 Frequency of down-regulation of expression of DUX-related genes in normal tissues and cervical carcinomas
Hypermethylation of genomic 3.3-kb repeats is frequent event in HPV-positive cervical cancer
Down-regulation of mRNA
Normal cervical tissues
Adjacent to tumors nonmalignant cervical tissues
P = 0.003**
Cervical cancer cell lines
Down-regulation was defined as the ratio normal/tumor exhibiting at least threefold reduction of mRNA level in tumor or the absence of mRNA expression.
* Products of PCR were absent in adjacent normal tissue as well as matched tumor.
** Fisher's exact test
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