Hypermethylation of genomic 3.3-kb repeats is frequent event in HPV-positive cervical cancer

BMC Medical Genomics

Table 1 Frequency of down-regulation of expression of DUX-related genes in normal tissues and cervical carcinomas

Samples	No. tested	Down-regulation of mRNA
Normal cervical tissues	5	0
Adjacent to tumors nonmalignant cervical tissues	24	5 (20.8%)*
Tumors	44	30 (68.2%)
		P = 0.003**
Cervical cancer cell lines	5	4

Down-regulation was defined as the ratio normal/tumor exhibiting at least threefold reduction of mRNA level in tumor or the absence of mRNA expression.
* Products of PCR were absent in adjacent normal tissue as well as matched tumor.
** Fisher's exact test

ISSN: 1755-8794