Figure 3

Detailed composition of gene expression modules identified by the hierarchical clustering algorithm (highlighted boxes in Figure 2). Genes in each module are given by MGI ID along the vertical axis. The same gene order is presented along the horizontal axis, as shown for (I). Module (I) is strongly enriched in genes whose products function primarily in the cardiac muscle contractile apparatus (6/9). Note that some genes are represented by two probes (e.g. TPM1) and counted only once. The dendrogram for this module is given on the left (bold section in Figure 2). A heatmap representing the relative expression of each gene over the different cardiac diseases is shown on the right. In the heatmap, color indicates the Z-score of expression relative to the mean over all diseases. Modules (II) and (ii) are enriched in genes involved in generation of precursor metabolites and energy (16/20). Modules (III) and (iii) are entirely comprised of genes involved in protein translation (20/20). Genes whose primary function is not known to match these groups are indicated using italic font.