Figure 4

Top scoring motifs detected in the promoter sequence of genes in the contractile, energy generation, and protein translation modules (Figure 3). From the left, columns give: (1) The motif logo; (2) IUPAC consensus sequence(s); (3) Interval relative to the transcription start site in which motif enrichment was observed (+2 to -2 for GSEA matches in which no enrichment detected in the core promoter); (4) P-value of enrichment, identified by IAMMS (ND indicates detection by GSEA); (5) Q-value of enrichment by GSEA (ND indicates detection by IAMMS); (6) Mean phylogenetic conservation score (motifs identified by GSEA are conserved by definition, and thus < -2); (7) Similarity to known motifs. Motifs are ordered based on position relative to the transcription start site or q-value for non-position specific motifs detected by GSEA. IUPAC ambiguity codes are R (A or G), Y (C or T), W (A or T), S (C or G), and N (A, T, C, or G).