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Table 1 The pattern of motifs in the core promoter has a significant association with gene expression in a group of holdout genes not used in motif discovery analysis.

From: Identification of gene co-regulatory modules and associated cis-elements involved in degenerative heart disease

  

Module

Correlation (microarray):

Contractile

Energy Generation

Protein Translation

  

High

Low

High

Low

High

Low

Pattern:

Yes:

74

1638

152

1371

35

178

 

No:

13

768

25

437

51

1429

Odds Ratio:

2.66 (1.46 – 5.28)

 

1.93 (1.24 – 3.13)

 

5.50 (3.37 – 8.89)

 

Fisher's p <

5.65e-4

2.03e-3

1.16e-11

  1. Contingency tables show the relationship between the pattern of motifs in the core promoter region and the expression patterns of genes in the test group (n = 3473), not used during motif the discovery procedure. The correlation thresholds were set to r > 0.8 (high) and r < 0 (low). The odds ratio measures the strength of association between the pattern of motifs in each promoter and the pattern of expression. The 95% confidence interval of the odds ratio is shown in parentheses. The p-value calculated using Fisher's exact test is given in the bottom row.
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BMC Medical Genomics

ISSN: 1755-8794

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