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Table 2 Biological pathways repressed by hypermethylation

From: Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer

Pathways Downregulated genes
(1286)
Hypermethylated and downregulated genes
(55)
Fisher's Exact Test p-values§
  Input genes in pathway Corrected p-value Input genes in pathway Genes in pathway Corrected p-value  
Cell adhesion molecules 14 1.95E-164 4 ITFAV, CLDN11, NEO1, CDH2 0 0.002*
Tight junction 13 1.40E-03 3 CLDN11, PPP2R4, INADL 9.93E-07 0.016*
PPAR signaling pathway 6 1.17E-01 2 CPT1A, SLC27A6 5.20E-03 0.024*
Leukocyte transendothelial migratio'n 9 2.34E-01 1 CLDN11 2.51E-02 0.326
  1. Pathways listed are all pathways regulated by hypermethylated and downregulated genes, determined by Pathway Express corrected p-value < 0.05.
  2. § Pathway enrichment p-values were calculated using a one-tail Fisher's exact test. Asterisks show p-value < 0.05