Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer

Table 2 Biological pathways repressed by hypermethylation

Pathways	Downregulated genes (1286)		Hypermethylated and downregulated genes (55)			Fisher's Exact Test p-values^§
	Input genes in pathway	Corrected p-value	Input genes in pathway	Genes in pathway	Corrected p-value
Cell adhesion molecules	14	1.95E-164	4	ITFAV, CLDN11, NEO1, CDH2	0	0.002*
Tight junction	13	1.40E-03	3	CLDN11, PPP2R4, INADL	9.93E-07	0.016*
PPAR signaling pathway	6	1.17E-01	2	CPT1A, SLC27A6	5.20E-03	0.024*
Leukocyte transendothelial migratio'n	9	2.34E-01	1	CLDN11	2.51E-02	0.326

Pathways listed are all pathways regulated by hypermethylated and downregulated genes, determined by Pathway Express corrected p-value < 0.05.
^§ Pathway enrichment p-values were calculated using a one-tail Fisher's exact test. Asterisks show p-value < 0.05

ISSN: 1755-8794