TY - JOUR AU - Buffart, Tineke E. AU - Tijssen, Marianne AU - El-Bchiri, Jamila AU - Duval, Alex AU - Wiel, Mark A. van de AU - Ylstra, Bauke AU - Meijer, Gerrit A. AU - Carvalho, Beatriz PY - 2009 DA - 2009/06/29 TI - NMD inhibition fails to identify tumour suppressor genes in microsatellite stable gastric cancer cell lines JO - BMC Medical Genomics SP - 39 VL - 2 IS - 1 AB - Gastric cancers frequently show chromosomal alterations which can cause activation of oncogenes, and/or inactivation of tumour suppressor genes. In gastric cancer several chromosomal regions are described to be frequently lost, but for most of the regions, no tumour suppressor genes have been identified yet. The present study aimed to identify tumour suppressor genes inactivated by nonsense mutation and deletion in gastric cancer by means of GINI (gene identification by nonsense mediated decay inhibition) and whole genome copy number analysis. SN - 1755-8794 UR - https://doi.org/10.1186/1755-8794-2-39 DO - 10.1186/1755-8794-2-39 ID - Buffart2009 ER -