Validation of previously identified serum biomarkers for breast cancer with SELDI-TOF MS: a case control study

BMC Medical Genomics

Table 2 Intensities in cases and controls of the peaks most likely representing the previously reported proteins [2–4] in order of m/z

	Breast cancer cases (n = 47)		Healthy controls (n = 48)			Mann-Whitney U test	ROC-curve
M/z	Median intensity	IQR	Median intensity	IQR	Intensity in cases vs. controls	p-value	AUC	95%CI
4276	11.04	2.10 – 29.31	39.48	14.17 – 77.58	Decreased	<0.0001	0.716	0.61–0.82
4292	14.54	8.52 – 29.54	42.07	29.67 – 63.39	Decreased	<0.0001	0.770	0.67–0.87
8129	25.92	20.48 – 28.19	26.05	21.06 – 28.08	-	0.870	0.510	0.39–0.63
8941	31.27	24.07 – 44.88	73.47	48.69 – 86.72	Decreased	<0.0001	0.830	0.75–0.91

M/z = Mass to Charge ratio, IQR = Inter-Quartile Range, ROC-curve = Receiver Operating Characteristic curve, AUC = Area Under the Curve, 95%CI = 95% Confidence Interval

ISSN: 1755-8794