Skip to main content

Table 2 Expression regulation of rat orthologs of human genes localised in DN susceptibility loci and not represented on the Affymetrix arrays.

From: Functional annotations of diabetes nephropathy susceptibility loci through analysis of genome-wide renal gene expression in rat models of diabetes mellitus

     GK vs WKY STZ-WKY vs WKY STZ-WKY v GK
Human Ensembl Description Symbol Rat Ensembl TR p-value TR p-value TR p-value
(ENSG00000)    (ENSRNO G000000)       
Human 3q23
175066 Glycerol kinase 5 GK5 10942 1.00 Ns 0.66 0.026 0.67 2 × 10-3
114120 Solute carrier family 25, member 36 SLC25A36 39085 1.28 Ns 1.54 4 × 10-3 1.21 Ns
175093 SPRY domain-containing SOCS box protein 4 SPSB4 12862 0.78 Ns 0.37 5 × 10-3 0.47 0.013
114126 Transcription factor Dp-2 (E2F dimerization partner 2) TFDP2 11241 0.76 Ns 1.56 Ns 2.04 Ns
114127 5'-3' exoribonuclease 1 XRN1 10027 0.71 Ns 0.66 0.030 0.93 Ns
177311 Zinc finger and BTB domain-containing protein 38 ZBTB38 12386 1.08 Ns 1.27 0.026 1.17 Ns
206250 Protein coding sequence - 22555 0.81 Ns 0.82 Ns 1.01 Ns
Human 7q33
146856 ATP/GTP binding protein-like 3 AGBL3 10397 0.95 Ns 0.52 1 × 10-4 0.55 3 × 10-4
198074 Aldo-keto reductase 1 member B10 AKR1B10 27433 1.94 0.035 0.77 Ns 0.40 1 × 10-4
122783 Uncharacterized protein C7orf49 C7orf49 26958 0.95 Ns 0.59 0.016 0.62 5 × 10-3
Human 18q22.3-23
179981 Teashirt zinc finger homeobox 1 TSHZ1 16246 0.91 Ns 1.00 Ns 1.10 Ns
141665 F-box only protein 15 FBXO15 38225 0.72 Ns 0.69 Ns 0.97 Ns
130856 Zinc finger protein 236 ZNF236 16303 1.45 0.025 1.48 0.011 1.02 Ns
166540 zinc finger protein 407 ZNF407 16008 0.87 Ns 0.77 0.015 0.88 Ns
101493 Zinc finger protein 516 ZNF516 16258 1.07 Ns 1.20 Ns 1.12 Ns
Human 20p12.3-13
149451 Disintegrin and metalloproteinase 33 ADAM33 21242 0.85 Ns 1.28 Ns 1.51 Ns
101222 Uncharacterized protein C20orf28 C20orf28 21247 1.19 Ns 0.80 Ns 0.67 0.016
101311 Unc-112-related protein 1 (Kindlin-1) C20orf42 21274 0.70 0.050 0.53 2.2 × 10-3 0.75 Ns
125872 Uncharacterized protein C20orf75 C20orf75 32989 1.65 Ns 5.48 1 × 10-3 3.31 1 × 10-3
171984 Uncharacterized protein C20orf196 C20orf196 21268 1.40 Ns 1.22 Ns 0.87 Ns
125885 Minichromosome maintenance complex component 8 MCM8 21272 2.63 Ns 2.82 Ns 1.08 Ns
171864 Prion protein 2 PRND 21260 0.64 Ns 0.53 Ns 0.83 Ns
101236 RING finger protein 24 RNF24 21250 0.81 Ns 0.60 0.010 0.74 Ns
088827 Sialic acid-binding Ig-like lectin 1 SIGLEC1 21243 0.73 0.033 0.81 Ns 1.11 Ns
149345 Putative ubiquitin-conjugating enzyme E2 D3-like U2D3L 13741 1.27 Ns 0.64 0.020 0.51 2 × 10-3
  1. The EnsMart browser http://http:www.ensembl.org/ was used to identify human-rat homologies (synteny conservation) in regions of the human genome associated with DN. Transcription ratios (TR) between models were assessed by QRT-PCR with kidney samples of GK, STZ-WKY and WKY rats previously used to hybridize microarrays. Ns, not statistically significant.