Novel transcriptional profile in wrist muscles from cerebral palsy patients

Smith, Lucas R; Pontén, Eva; Hedström, Yvette; Ward, Samuel R; Chambers, Henry G; Subramaniam, Shankar; Lieber, Richard L

doi:10.1186/1755-8794-2-44

BMC Medical Genomics

Table 3 Significantly altered genes in functional categories

From: Novel transcriptional profile in wrist muscles from cerebral palsy patients

		P-Values					P-Values
GENE	Ratio	MAS5	RMA	GCRMA	GENE	Ratio	MAS5	RMA	GCRMA
Neuromuscular Junction					Muscle Contraction and Structure
KCNN3	12.98	0.013	0.011	0.018	MYH1	8.57	0.001	0.001	0.000
COL4A3	2.89	0.043	0.014	0.019	MYH4	4.33	0.001	0.002	0.015
LAMB2	1.74	0.042	0.018	0.015	NEB	2.54	0.015	0.008	0.013
Excitation Contraction Coupling					MYBPC2	2.16	0.027	0.004	0.004
PVALB	62.60	0.001	0.004	0.001	DMD	2.11	0.023	0.020	0.027
ATP2B2	2.60	0.033	0.023	0.021	LDB3	1.93	0.030	0.015	0.015
TRDN	2.38	0.028	0.019	0.017	Metabolism/Mitochondria Related
ATP2C1	2.30	0.046	0.047	0.041	WARS	0.64	0.044	0.040	0.019
PDE4DIP	2.10	0.005	0.003	0.004	CAV1	0.64	0.037	0.013	0.017
CALM1	1.70	0.005	0.004	0.008	CERK	0.63	0.033	0.006	0.014
CACNB1	1.51	0.045	0.014	0.017	A2M	0.62	0.015	0.016	0.010
FKBP1A	0.56	0.039	0.016	0.011	MDH1	0.60	0.050	0.017	0.011
Myogenesis/Fiber type pathways					PECI	0.58	0.029	0.024	0.012
GDF8	3.65	0.025	0.032	0.007	MRPL35	0.57	0.040	0.043	0.037
IGF1	2.63	0.013	0.010	0.008	MRPS18B	0.56	0.009	0.002	0.001
IGFBP5	2.48	0.002	0.000	0.000	SLC25A20	0.55	0.044	0.049	0.022
PLCB1	2.34	0.028	0.014	0.007	CPT2	0.54	0.044	0.022	0.013
RASA4	2.26	0.037	0.027	0.029	MRPS12	0.53	0.044	0.008	0.010
PPP3CA	1.95	0.012	0.003	0.005	UCP2	0.51	0.030	0.023	0.015
PBX1	1.86	0.028	0.010	0.007	MLYCD	0.48	0.017	0.004	0.001
CALM1	1.70	0.005	0.004	0.008	PPIF	0.48	0.014	0.011	0.010
MBNL1	1.55	0.033	0.015	0.024	ADM	0.47	0.019	0.012	0.018
MEF2A	1.53	0.028	0.006	0.007	UCP3	0.47	0.014	0.010	0.007
NEO1	1.44	0.015	0.005	0.001	ALDH6A1	0.46	0.023	0.013	0.007
HMGB1	1.34	0.015	0.013	0.015	ACSL1	0.43	0.014	0.008	0.004
Extracellular Matrix					GOT1	0.42	0.039	0.027	0.021
MFAP5	3.64	0.012	0.004	0.014	TST	0.41	0.015	0.002	0.001
COL4A3	2.89	0.043	0.014	0.019	MT1G	0.37	0.015	0.009	0.011
COL21A1	2.86	0.021	0.022	0.015	LPL	0.35	0.013	0.010	0.007
KAL1	2.57	0.002	0.003	0.003	RETSAT	0.35	0.002	0.006	0.005
MATN2	2.24	0.013	0.011	0.007	MT1M	0.34	0.015	0.006	0.004
CILP	2.09	0.035	0.043	0.034	MT1X	0.32	0.014	0.012	0.010
SMC3	1.88	0.021	0.026	0.019	GLUL	0.31	0.018	0.017	0.013
ECM2	1.86	0.037	0.035	0.021	MT2A	0.29	0.015	0.013	0.011
LAMB2	1.74	0.042	0.018	0.015	MT1H	0.29	0.015	0.015	0.012
COL4A1	0.51	0.048	0.032	0.015	MT1F	0.27	0.019	0.012	0.009
BSG	0.48	0.033	0.026	0.030	MT1E	0.26	0.012	0.006	0.005
COL4A2	0.43	0.012	0.010	0.006	LIPE	0.22	0.028	0.001	0.002

Table of genes within function groups related to skeletal muscle. Groups defined by ratio is the expression ratio of CP:CTRL. P-values are listed for the three separate preprocessing algorithms used (MAS5, RMA, GCRMA).

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ISSN: 1755-8794

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