Table 2 Interacting Proteins
From: Host sequence motifs shared by HIV predict response to antiretroviral therapy
Entrez ID | Symbol | Gene Name | Significant ELMs Present |
|---|---|---|---|
59 | ACTA2 | actin, alpha 2, smooth muscle, aorta | The localization of the HIV-1 reverse transcription complex to actin microfilaments is mediated by the interaction of a reverse transcription complex component (HIV-1 Matrix) with actin, but not vimentin (intermediate filaments) or tubulin (microtubules) |
60 | ACTB | Actin, beta | Eukaryotic beta-actin binds to either the large subunit (p66) of HIV-1 reverse transcriptase or to the HIV-1 Pol precursor polyprotein in vitro; this interaction is believed to be important for the secretion of HIV-1 virions |
70 | ACTC1 | actin, alpha, cardiac muscle 1 | The localization of the HIV-1 reverse transcription complex to actin microfilaments is mediated by the interaction of a reverse transcription complex component (HIV-1 Matrix) with actin, but not vimentin (intermediate filaments) or tubulin (microtubules) |
1457 | CSNK2A1 | casein kinase 2, alpha 1 | Casein kinase II phosphorylates HIV-1 RT p66 and p51 in human cells |
3439, 3440, 3449 | IFNA1, IFNA2, IFNA16 | Â | IFN-alpha interferes with the initiation of HIV-1 reverse transcription resulting in a significant reduction in the relative levels of HIV-1 proviral DNA |
3458 | IFNG | Interferon, gamma | Up-regulation of LMP7 by IFN-gamma enhances proteasomal degradation of HIV-1 RT and presentation of the VIYQYMDDL epitope derived from HIV-1 RT |
4772, 4773 | NFACT1, NFACT2 | nuclear factor of activated T-cells | NFATc facilitates HIV-1 RT reverse transcription activity and enhances HIV-1 infectivity in human T cells |
5286 | PIK3C2A | phosphoinositide-3-kinase, class 2, alpha polypeptide | HIV-1 RT heterodimer expressed in bacteria can be phosphorylated in vitro by several purified mammalian protein kinases including auto-activated protein kinase (PK), CKII, cytosolic protamine kinase (CPK), myelin basic protein kinase 1 (MBPK1), and PRKC |
5578, 5579, 5580, 5581, 5584, 5588, 5590 | PRKCA, PRKCB1, PRKCD, PRKCE, PRKCI, PRKCQ, PRKCZ | Â | HIV-1 RT heterodimer expressed in bacteria can be phosphorylated in vitro by several purified mammalian protein kinases including auto-activated protein kinase (PK), CKII, cytosolic protamine kinase (CPK), myelin basic protein kinase 1 (MBPK1), and PRKC |
5594, 5604, 6300 | MAPK1, MAP2K1, MAPK12 | mitogen-activated protein kinase 1 | MEK1 in HIV-1 producer cells is able to activate virion-associated MAPK in trans, and the activated MAPK facilitates efficient disengagement of the HIV-1 reverse transcription complex from the cell membrane and subsequent nuclear translocation |
5696 | PSMB8 | proteasome subunit, beta type, 8 | Up-regulation of LMP7 by IFN-gamma enhances proteasomal degradation of HIV-1 RT and presentation of the VIYQYMDDL epitope derived from HIV-1 RT |
6117, 6118, 6119 | RPA1, RPA2, RPA3 | Â | Replication protein A and HIV-1 nucleocapsid protein interfere with the strand displacement DNA synthesis of HIV-1 reverse transcriptase by binding to the displaced strand and keeping it away from the newly synthesized strand |
7150 | TOP1 | topoisomerase (DNA) I | Topoisomerase I (topo I) enhances HIV-1 reverse transcriptase activity in vitro and this effect can be inhibited by the topo I-specific inhibitor camptothecin |
7157 | TP53 | tumor protein p53 (Li-Fraumeni syndrome) | Tumor suppressor protein p53 displays 3' -> 5' exonuclease activity, and interaction of p53 with HIV-1 reverse transcriptase (RT) can provide a proofreading function for HIV-1 RT |
10527 | IPO7 | importin 7 | Importin 7, an import receptor for ribosomal proteins and histone H1, is involved in the active nuclear import of the intracellular HIV-1 reverse transcription complex (RTC) containing HIV-1 RT, IN, NC, MA, and Vpr |
29935 | RPA4 | replication protein A4, 34 kDa | Replication protein A and HIV-1 nucleocapsid protein interfere with the strand displacement DNA synthesis of HIV-1 reverse transcriptase by binding to the displaced strand and keeping it away from the newly synthesized strand |
50810 | Â | hepatoma-derived growth factor, related protein 3 | Hepatoma-derived growth factor 2 (HRP2) restores salt-stripped HIV-1 preintegration complex (PIC) activity in vitro |
60489 | Â | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | Vif-negative HIV-1 produced from 293T cells transiently expressing hA3G are impaired in early and late viral DNA production, and in viral infectivity, which are correlated with an inability of tRNA(3)(Lys) to prime reverse transcription |