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Table 2 Canonical pathways significant in the transition from normal prostate to localized prostate cancer (functional annotation by Ingenuity)*

From: Candidate pathways and genes for prostate cancer: a meta-analysis of gene expression data

Pathway -Log (P)
Calcium signaling 4.62
NRF2-mediated oxidative stress response 4.05
Actin cytoskeleton signaling 3.31
Tight junction signaling 3.19
Synaptic long term potentiation 3.05
Hepatic fibrosis/hepatic stellate cell activation 2.99
Integrin signaling 2.58
EGF signaling 2.45
GM-CSF signaling 2.38
Regulation of actin-based motility by Rho 2.12
Wnt/beta-catenin signaling 2.04
PDGF signaling 2.04
Xenobiotic metabolism signaling 1.98
Chemokine signaling 1.94
Arginine and proline metabolism 1.94
Cell cycle: G1/S checkpoint regulation 1.86
ERK/MAPK signaling 1.79
cAMP-mediated signaling 1.77
VEGF signaling 1.65
Leukocyte extravasation signaling 1.61
Neuregulin signaling 1.60
Nitric oxide signaling in the cardiovascular system 1.54
Glutathione metabolism 1.54
LPS/IL-1 mediated inhibition of RXR function 1.52
Purine metabolism 1.41
Fatty acid biosynthesis 1.34
Aryl hydrocarbon receptor signaling 1.34
Glucocorticoid receptor signaling 1.34
  1. *Lists of the significant genes in each pathway are shown in Additional file 5.