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Table 4 Canonical pathways identified in the combined analysis of genes differentially expressed between the transitions from normal prostate to primary nonmetastatic prostate cancer and from primary nonmetastatic to metastatic prostate cancer*

From: Candidate pathways and genes for prostate cancer: a meta-analysis of gene expression data

Pathway -Log(P)
Integrin signaling 4.42
Hepatic fibrosis/hepatic stellate cell activation 3.50
Actin cytoskeleton signaling 3.27
Tight junction signaling 3.16
Chemokine signaling 3.10
Calcium signaling 2.60
IGF-1 signaling 2.54
Aryl hydrocarbon receptor signaling 2.10
Regulation of actin-based motility by Rho 2.10
Nitric oxide signaling in the cardiovascular system 2.05
Beta-alanine metabolism 2.03
Wnt/β-catenin signaling 1.63
VEGF signaling 1.63
p53 signaling 1.48
NRF2-mediated oxidative stress response 1.43
Arginine and proline metabolism 1.42
Cardiac β-adrenergic signaling 1.38
cAMP-mediated signaling 1.38
Cell cycle: G2/M DNA damage checkpoint regulation 1.33
  1. *Lists of the genes for each pathway are shown in Additional file 8.