Table 4 Canonical pathways identified in the combined analysis of genes differentially expressed between the transitions from normal prostate to primary nonmetastatic prostate cancer and from primary nonmetastatic to metastatic prostate cancer*

Integrin signaling

4.42

Hepatic fibrosis/hepatic stellate cell activation

3.50

Actin cytoskeleton signaling

3.27

Tight junction signaling

3.16

Chemokine signaling

3.10

Calcium signaling

2.60

IGF-1 signaling

2.54

Aryl hydrocarbon receptor signaling

2.10

Regulation of actin-based motility by Rho

2.10

Nitric oxide signaling in the cardiovascular system

2.05

Beta-alanine metabolism

2.03

Wnt/β-catenin signaling

1.63

VEGF signaling

1.63

p53 signaling

1.48

NRF2-mediated oxidative stress response

1.43

Arginine and proline metabolism

1.42

Cardiac β-adrenergic signaling

1.38

cAMP-mediated signaling

1.38

Cell cycle: G2/M DNA damage checkpoint regulation

1.33