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Table 1 List of most differentially regulated genes in 4OHT-treated K13 ER-HUVECs.

From: Integrated microarray and multiplex cytokine analyses of Kaposi's Sarcoma Associated Herpesvirus viral FLICE Inhibitory Protein K13 affected genes and cytokines in human blood vascular endothelial cells

 

Gene Name

Gene

Entrez Gene

Fold Change

Up-regulated genes

1

chemokine (C-C motif) ligand 2

CCL2

6347

71.4

2

ubiquitin D

UBD

10537

58.4

3

chemokine (C-C motif) ligand 20

CCL20

6364

53.1

4

chemokine (C-C motif) ligand 5

CCL5

6352

48.3

5

chemokine (C-X-C motif) ligand 10

CXCL10

3627

47.7

6

vascular cell adhesion molecule 1

VCAM1

7412

46.0

7

selectin E (endothelial adhesion molecule 1)

SELE

6401

35.4

8

superoxide dismutase 2, mitochondrial

SOD2

6648

35.2

9

chemokine (C-X-C motif) ligand 3

CXCL3

2921

33.8

10

chemokine (C-X-C motif) ligand 2

CXCL2

2920

32.2

11

interleukin 8

IL8

3576

31.5

12

chromosome 15 open reading frame 48

C15orf48

84419

29.6

13

solute carrier family 7 (cationic amino acid transporter)

SLC7A2

6542

23.2

14

chemokine (C-X3-C motif) ligand 1

CX3CL1

6376

22.3

15

intercellular adhesion molecule 1 (CD54)

ICAM1

3383

22.2

16

tumor necrosis factor, alpha-induced protein 6

TNFAIP6

7130

21.2

17

interleukin 6 (interferon, beta 2)

IL6

3569

21.1

18

colony stimulating factor 2 (granulocyte-macrophage)

CSF2

1437

15.1

19

interferon stimulated exonuclease gene 20 kDa

ISG20

3669

13.6

20

chemokine (C-X-C motif) ligand 5

CXCL5

6374

13.0

21

laminin, gamma 2

LAMC2

3918

12.7

22

tumor necrosis factor, alpha-induced protein 3

TNFAIP3

7128

12.5

23

matrix metallopeptidase 10 (stromelysin 2)

MMP10

4319

11.5

24

tumor necrosis factor, alpha-induced protein 2

TNFAIP2

7127

11.3

25

Epstein-Barr virus induced gene 3

EBI3

10148

9.8

26

tumor necrosis factor (ligand) superfamily, member 13b

TNFSF13B

10673

9.6

27

phospholipase A1 member A

PLA1A

51365

9.4

28

GTP cyclohydrolase 1 (dopa-responsive dystonia)

GCH1

2643

9.0

29

nuclear factor of kappa light polypeptide gene enhancer, alpha

NFKBIA

4792

8.3

30

proteasome (prosome, macropain) subunit, beta type, 9

PSMB9

5698

7.9

31

Chemokine (C-X-C motif) 1

CXCl1

2919

7.7

32

histone cluster 2, H2aa3

HIST2

723790

7.5

33

HLA-G histocompatibility antigen, class I, G

HLA-G

3135

7.2

34

hydroxysteroid (11-beta) dehydrogenase 1

HSD11B1

3290

7.2

35

chemokine (C-X-C motif) receptor 7

CXCR7

57007

7.0

36

major histocompatibility complex, class I, B

HLA-B

3106

6.3

37

nuclear receptor coactivator 7

NCOA7

135112

6.1

38

myxovirus (influenza virus) resistance 2 (mouse)

MX2

4600

5.8

39

radical S-adenosyl methionine domain containing 2

RSAD2

91543

5.6

40

TNFAIP3 interacting protein 1

TNIP1

10318

5.5

41

tissue factor pathway inhibitor 2

TFPI2

7980

5.4

42

interleukin 32

IL32

9235

5.3

43

Nibrin

NBN

4683

5.2

44

receptor (chemosensory) transporter protein 4

RTP4

64108

5.2

45

baculoviral IAP repeat-containing 3

BIRC3

330

5.1

46

interleukin 7 receptor /// interleukin 7 receptor

IL7R

3575

5.0

47

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

TAP1

6890

5.0

48

papilin, proteoglycan-like sulfated glycoprotein

PAPLN

89932

4.9

49

Major histocompatibility complex, class I, F

HLA-F

3134

4.9

50

myosin, light chain kinase

MYLK

4638

4.9

Down-regulated genes

1

extracellular link domain containing 1

XLKD1

10894

11.1

2

chemokine (C-C motif) ligand 14

CCL14

6358

11.0

3

ADAM metallopeptidase with thrombospondin type 1 motif, 18

ADAMTS18

170692

7.8

4

LIM domain binding 2

LDB2

9079

6.7

5

keratin 18

KRT18

3875

5.3

6

dual specificity phosphatase 4

DUSP4

1846

5.3

7

ribonuclease, RNase A family, 1 (pancreatic)

RNASE1

6035

4.7

8

periostin, osteoblast specific factor

POSTN

10631

4.7

9

insulin-like growth factor binding protein 5

IGFBP5

3488

4.6

10

regulator of G-protein signalling 5

RGS5

8490

4.6

11

uroplakin 1B /// regulator of G-protein signalling 5

UPK1B

7348

4.5

12

regulator of G-protein signalling 4

RGS4

5999

5.5

13

Palmdelphin

PALMD

54873

3.8

14

latent transforming growth factor beta binding protein 2

LTBP2

4053

3.2

15

C-X-C chemokine receptor type 4

CXCR4

7852

3.1