Hepatic inflammation mediated by hepatitis C virus core protein is ameliorated by blocking complement activation

BMC Medical Genomics

Table 1 Gene functional analysis for selected genes from three experiments

Category	Genes in category	Genes in category (%)	Selected genes in category	Selected genes in category (%)	P-value^†	FDR_P^‡
Experiment I
Biological Process
GO:6953: acute-phase response	19	0.189	3	17.65	0.0000	< .0001
Experiment II
Biological Process
GO:9058: biosynthesis	853	8.492	26	20.47	0.0000	< .0001
Molecular Function
GO:3824: catalytic activity	4096	34.96	73	54.07	0.0000	< .0001
GO:16740: transferase activity	1383	11.81	28	20.74	0.0020	0.022
GO:16491: oxidoreductase activity	570	4.866	14	10.37	0.0060	0.039
GO:30234: enzyme regulator activity	462	3.944	12	8.889	0.0071	0.039
GO:16829: lyase activity	113	0.965	5	3.704	0.0098	0.0431
Experiment III
Biological Process
GO:9058: biosynthesis	853	8.492	19	20.43	0.0003	0.0057
Molecular Function
GO:16740: transferase activity	1383	11.81	25	26.04	0.0001	0.002
GO:30234: enzyme regulator activity	462	3.944	12	12.5	0.0004	0.0027
GO:3824: catalytic activity	4096	34.96	50	52.08	0.0004	0.0027

Genes in category: All genes belonging to a category
Genes in category (%): Genes belonging to the category as a percentage of the total number of genes analyzed (20,871)
Selected genes in category: Selected genes belonging to a category
Selected genes in category (%): Selected genes belonging to the category as a percentage of all genes belonging to that category
^†Student's t-test.
^‡Adjusted P value for Benjamini and Hochberg method (false discovery rate; FDR).

ISSN: 1755-8794