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Table 2 QPCR results of verification group 1

From: Verification of genes differentially expressed in neuroblastoma tumours: a study of potential tumour suppressor genes

Gene

Cytoband

t-test

Sign.

FC

Earlier suggested by

ACD

16q22.1

0.1029

n.s.

4

 

ACP1

2p25

0.0023

**

4

 

ATBF1

16q22.3

1.70E-05

***

9

 

BRSK2

11p15.5

2.40E-04

***

21

 

C2orf25

2q23.3

0.0929

n.s.

3

 

C5orf13

5q22.1

0.0102

*

4

 

CACNA2D3

3p21.1

0.0019

**

133

[31]

CBFB

16q22.1

2.04E-05

***

9

 

CCND1

11q13

0.0012

**

6

 

CDC5L

6p21

0.0072

**

15

 

CHCHD2

7p11.2

0.0041

**

4

 

CLASP1

2q14.2-q14.3

0.0021

**

12

 

CNTNAP2

7q35-q36

0.0011

**

287

 

CXXC4

4q24

0.0350

*

10

 

DBH

9q34

0.0039

**

15

[15, 32]

DCUN1D2

13q34

0.0027

**

26

 

DCX

Xq22.3-q23

0.0091

**

9

 

DDC

7p11

0.0156

*

24

[32, 33]

DGUOK

2p13

0.0047

**

10

 

DPYSL3

5q32

0.0100

**

23

[33]

EIF2S3

Xp22.11

0.0024

**

4

 

FLJ20323

7p21.3

0.0015

**

10

 

FSCN1

7p22

0.0091

**

4

 

FSD1

19p13.3

0.0077

**

8

 

FUS

16p11.2

0.0350

*

15

 

FUSIP1

1p36.11

0.0128

*

22

 

GATA2

3q21.3

0.0260

*

4

[32]

GATA3

10p15

0.0018

**

6

[15]

GDF1; LASS1

19p12

0.0409

*

10

 

GNB1

1p36.33

0.0028

**

10

[15, 32]

H3F3B

1q41

0.0057

**

4

 

HDAC2

6q21

0.0036

**

11

 

HNRPDL

4q21.22

0.0025

**

7

 

HNRPH3

10q22

0.0086

**

7

 

IDH2

15q26.1

0.0023

**

6

 

ILF2

1q21.3

0.0161

*

6

 

ISL1

5q11.2

0.0074

**

6

 

ITGAE

17p13

n.d.

n.d.

n.d.

 

KIAA0408

6q22.33

3.96E-04

***

15

 

KIDINS220

2p24

0.0014

**

15

 

LOC440434

17q12

0.0264

*

11

 

MAOA

Xp11.3

0.0105

*

12

 

MARCKSL1

1p35.1

0.0107

*

5

 

MCM6

2q21

0.0301

*

5

 

MCG12760

1p36.13

n.d.

n.d.

n.d.

 

MCG4655

16q22.1

0.3849

n.s.

1

 

MTF2

1p22.1

7.83E-04

***

10

 

NACA

12q13.3

0.0240

*

4

 

NDUFS4

5q11.1

5.06E-04

***

5

 

NONO

Xq13.1

0.0015

**

6

 

NSUN6

10p12.31

0.0010

***

20

 

PAFAH1B3

19q13.1

0.0044

**

8

 

PALM

19p13.3

2.28E-04

***

7

 

PHOX2A

11q13.2

0.0223

*

26

 

PHOX2B

4p12

0.0042

**

18

[15]

PILRB

7q22.1

0.0084

**

15

 

PKIA

8q21.11

8.69E-04

***

21

 

POU2F1

1q24.1-24.2

5.77E-04

***

20

 

POU4F2

4q31.2

0.0106

*

1518

[18, 34]

PRKRA

2q31.2

0.0042

**

18

 

RABL2B; RABL2A

2q13

0.0122

*

17

 

RAPGEF6

5q23.3

0.0097

**

37

[35]

REV1L

2q11.2

8.99E-04

***

9

 

RPL19

17q12

0.1034

n.s.

2

 

SEC61G

7p11.2

0.0140

*

7

 

SEPHS1

10p14

4.51E-04

***

6

 

SFRS3

6p21

0.0126

*

5

 

SHC1

1q21

0.0129

*

12

 

SLC18A1

8p21.3

0.0130

*

25

 

SLC35E2

1p36.33

0.0241

*

3

[15]

SLC6A2

16q12.2

0.0012

**

540

 

SMN1; SMN2

5q13

0.0104

*

8

 

SMPD4

2q21.1

0.0279

*

6

 

SPAST

2p22.3

2.48E-05

***

9

 

ST13

22q13.2

0.0324

*

5

 

TAF9B

Xq21.1

0.0243

*

7

 

TCP1

6q25.3

2.89E-04

***

6

 

TFAP2B

6p12.3

0.0115

*

13

[14, 31, 33, 34]

TH

11p15.5

0.0126

*

11

[15, 32]

TIA1

2p14

5.99E-05

***

16

 

TMSL8

Xq22.1

0.2105

n.s.

2

 

TNFRSF25

1p36.31

0.0717

n.s.

8

[15, 33, 36]

TOP2B

3p24.2

2.49E-04

***

4

 

TPRKB

2p13.2

0.0386

*

4

 

UBE2E3

2q31.3

0.0110

*

13

 

UCKL1

20q13.33

0.0013

**

11

 

VPS28

8q24.3

0.0090

**

9

 

XRCC5

2q35

0.0092

**

7

 

YWHAQ

2p25.1

0.0400

*

5

 
  1. Ver 1 = verification group 1; Cytoband = Chromosomal location; t-test = significance by Student's t-test; n.d. = not determined; Sign. = Significance level by Student's t-test, * p < 0,05, ** p < 0,01, *** p < 0,001, n.s. = not significant; FC = Fold change between groups. Transcripts selected for the second verification are highlighted in bold.
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BMC Medical Genomics

ISSN: 1755-8794

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