MicroRNA-125a is over-expressed in insulin target tissues in a spontaneous rat model of Type 2 Diabetes

BMC Medical Genomics

Table 2 MiRNA microarray analysis reveals differential expression between hyperglycaemic and normoglycaemic rats

Rank	miRNA	Fold change (GK vs. BN)	P-value	Adjusted P-value
Liver
1	miR-125a	5.61	0.001	0.104
2	miR-30e	1.56	0.009	0.522
3	miR-210	1.56	0.013	0.522
4	miR-221	1.60	0.015	0.522
5	miR-223	1.50	0.015	0.522
6	miR-365	1.41	0.029	0.592
7	miR-26b	1.51	0.031	0.592
8	miR-23a	2.30	0.032	0.592
9	miR-222	1.38	0.033	0.592
10	miR-29c	1.52	0.038	0.592
11	miR-30a-3p	1.32	0.045	0.592
12	miR-22	-1.39	0.050	0.592
Adipose tissue
1	miR-322	1.91	0.029	0.999
2	let-7c	-2.27	0.040	0.999
3	let-7b	-2.17	0.046	0.999
4	miR-29a	1.51	0.049	0.999
5*	miR-125a	1.97	0.078	0.999

Differences in miRNA expression levels in 4 hyperglycaemic GK rats compared to 4 normoglycaemic BN rats in liver and adipose tissue. For each tissue, one GK and one BN sample were hybridized to each array in a two-colour experiment (4 arrays per tissue). M-ratios therefore represent the log₂ intensity ratio in the two strains. The limma package from BioConductor was used to find miRNAs differentially expressed between GK and BN rats and the top ranking genes for each tissue are shown. * miR-125a is shown in this table to illustrate the potential overlap of signals detected in liver and adipose tissue.

ISSN: 1755-8794