Table 3 Functional profiling of differentially expressed genes in GK compared to BN rats in adipose tissue (n = 1075) and liver (n = 233) using GENECODIS.
KEGG pathway(s) | Number of genes | Corrected p-value |
|---|---|---|
Adipose tissue | Â | Â |
Prostaglandin and leukotriene metabolism | 10 | 0.001 |
Focal adhesion | ECM-receptor interaction | Hematopoietic cell lineage | Regulation of actin cytoskeleton | 4 | 0.002 |
ECM-receptor interaction | Hematopoietic cell lineage | 5 | 0.002 |
ECM-receptor interaction | 11 | 0.002 |
Glycolysis/Gluconeogenesis | 9 | 0.003 |
Focal adhesion | ECM-receptor interaction | 9 | 0.003 |
Arginine and proline metabolism | 8 | 0.005 |
Glycolysis/Gluconeogenesis | Fructose and mannose metabolism | 4 | 0.005 |
Glycolysis/Gluconeogenesis | Pentose phosphate pathway | Fructose and mannose metabolism | 3 | 0.012 |
Hematopoietic cell lineage | 9 | 0.015 |
Cell Communication | Focal adhesion | ECM-receptor interaction | 6 | 0.019 |
Fructose and mannose metabolism | 6 | 0.019 |
Porphyrin and chlorophyll metabolism | 5 | 0.029 |
Folate biosynthesis | 5 | 0.031 |
Metabolism of xenobiotics by cytochrome P450 | 7 | 0.033 |
Cytokine-cytokine receptor interaction | Focal adhesion | 3 | 0.033 |
Focal adhesion | 14 | 0.033 |
Valine, leucine and isoleucine degradation | 6 | 0.033 |
Cholera – Infection | 5 | 0.033 |
Fructose and mannose metabolism | Galactose metabolism | 3 | 0.033 |
Urea cycle and metabolism of amino groups | 4 | 0.033 |
Glycine, serine and threonine metabolism | 5 | 0.044 |
Liver | Â | Â |
Arginine and proline metabolism | 7 | 2.17E-06 |
Alanine and aspartate metabolism | Arginine and proline metabolism | 3 | 2.09E-05 |
Alanine and aspartate metabolism | 4 | 1.30E-04 |
Urea cycle and metabolism of amino groups | Arginine and proline metabolism | 3 | 0.0017 |
Prostaglandin and leukotriene metabolism | 4 | 0.0019 |
Valine, leucine and isoleucine degradation | Butanoate metabolism | 3 | 0.0030 |
Fatty acid metabolism | 3 | 0.0103 |
ECM-receptor interaction | 3 | 0.0361 |