Skip to main content

Table 3 Functional profiling of differentially expressed genes in GK compared to BN rats in adipose tissue (n = 1075) and liver (n = 233) using GENECODIS.

From: MicroRNA-125a is over-expressed in insulin target tissues in a spontaneous rat model of Type 2 Diabetes

KEGG pathway(s) Number of genes Corrected p-value
Adipose tissue   
Prostaglandin and leukotriene metabolism 10 0.001
Focal adhesion | ECM-receptor interaction | Hematopoietic cell lineage | Regulation of actin cytoskeleton 4 0.002
ECM-receptor interaction | Hematopoietic cell lineage 5 0.002
ECM-receptor interaction 11 0.002
Glycolysis/Gluconeogenesis 9 0.003
Focal adhesion | ECM-receptor interaction 9 0.003
Arginine and proline metabolism 8 0.005
Glycolysis/Gluconeogenesis | Fructose and mannose metabolism 4 0.005
Glycolysis/Gluconeogenesis | Pentose phosphate pathway | Fructose and mannose metabolism 3 0.012
Hematopoietic cell lineage 9 0.015
Cell Communication | Focal adhesion | ECM-receptor interaction 6 0.019
Fructose and mannose metabolism 6 0.019
Porphyrin and chlorophyll metabolism 5 0.029
Folate biosynthesis 5 0.031
Metabolism of xenobiotics by cytochrome P450 7 0.033
Cytokine-cytokine receptor interaction | Focal adhesion 3 0.033
Focal adhesion 14 0.033
Valine, leucine and isoleucine degradation 6 0.033
Cholera – Infection 5 0.033
Fructose and mannose metabolism | Galactose metabolism 3 0.033
Urea cycle and metabolism of amino groups 4 0.033
Glycine, serine and threonine metabolism 5 0.044
Liver   
Arginine and proline metabolism 7 2.17E-06
Alanine and aspartate metabolism | Arginine and proline metabolism 3 2.09E-05
Alanine and aspartate metabolism 4 1.30E-04
Urea cycle and metabolism of amino groups | Arginine and proline metabolism 3 0.0017
Prostaglandin and leukotriene metabolism 4 0.0019
Valine, leucine and isoleucine degradation | Butanoate metabolism 3 0.0030
Fatty acid metabolism 3 0.0103
ECM-receptor interaction 3 0.0361