Skip to main content

Table 1 Mouse Lung: Significantly differentially expressing genes

From: Induction of the interleukin 6/ signal transducer and activator of transcription pathway in the lungs of mice sub-chronically exposed to mainstream tobacco smoke

Description *Fold change
Xenobiotic Metabolism 1 2 3 4
Cytochrome P450, family 1(Cyp1a1) 24.20 -1.02 26.93 -1.11
Cytochrome P450, family 1(Cyp1b1) 7.26 1.05 7.79 1.05
Aryl-hydrocarbon receptor repressor (Ahrr) 2.46 -1.04 3.92 1.13
NAD(P)H dehydrogenase, quinone 1 (Nqo1) 2.64 1.06 3.70 -1.00
Redox Balance     
Carbonyl reductase 3 (Cbr3) 3.42 1.11 3.54 -1.03
homolog (S. cerevisiae) (Srxn1) 1.93 1.04 3.23 -1.06
Alcohol dehydrogenase 7 (class IV)(Adh7) 2.15 -1.02 3.22 1.08
Aldehyde dehydrogenase family 3, subfamily A1 (Aldh3a1) 3.08 1.09 3.08 1.07
Aldo-keto reductase family 1 2.03 1.03 2.34 1.09
Thioredoxin reductase 1 (Txnrd1) 2.06 1.03 2.32 1.05
Aldehyde oxidase 1 (Aox1) 1.24 1.08 2.23 1.16
Glutathione metabolism     
Glutamate-cysteine ligase, catalytic subunit (Gclc) 2.40 1.00 4.06 1.30
Glutamate-cysteine ligase, modifier subunit (Gclm) 1.87 1.00 2.14 -1.04
Glutathione reductase 1 (Gsr) 1.31 1.06 1.34 -1.00
Glutathione S-transferase, theta 2 (Gstt2) -1.38 1.08 -1.05 1.12
Oxidative stress, Inflammatory pathways     
Heme oxygenase (decycling) 1 (Hmox1) 2.32 -1.09 4.41 -1.08
Interleukin 6 (Il6) 1.06 1.38 2.48 1.12
Prostaglandin-endoperoxide synthase 2 (Ptgs2) 1.87 1.47 2.91 1.13
Suppressor of cytokine signaling 3 (Socs3) 1.41 1.16 1.70 1.05
Lectin, galactose binding, soluble 3 (Lgals3) 1.55 -1.09 1.53 -1.11
Tumor necrosis factor, alpha-induced protein 2 (Tnfaip2) 1.53 1.16 1.30 -1.05
Paraoxonase 3 (Pon3) 1.31 1.01 1.43 1.14
Molecular chaperones     
Heat shock protein 1A (Hspa1a) 2.37 -1.22 2.69 -1.46
Heat shock 70 kDa protein 4 like (Hspa4l) 1.52 -1.01 1.79 -1.03
Development     
keratin complex 1, acidic, gene 19 (Krt1-19) 1.60 1.05 1.68 -1.02
ADP-ribosylation factor related protein 2 (Arfrp2) -1.60 -1.02 -1.40 -1.08
Procollagen, type V, alpha 1 (Col5a1) -1.24 1.07 -1.38 -1.01
Signal transduction pathways     
Mitogen-activated protein kinase kinase kinase 6 (Map3k6) 1.44 -1.12 1.79 -1.17
PH domain and leucine rich repeat protein phosphatase 1.64 -1.03 1.12 -1.04
Breast cancer anti-estrogen resistance 3 (Bcar3) 1.30 -1.10 1.56 -1.02
Inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (Itpa) 1.22 1.08 1.06 1.01
Cytoplasmic tyrosine kinase, Dscr28C related (Drosophila) (Tec) -1.25 -1.03 1.04 1.08
Serine/threonine kinase 4 (Stk4) 1.47 1.01 -1.04 -1.17
Immediate early response 3 (Ier3) 1.42 1.03 1.47 -1.23
Sphingosine kinase 1 (Sphk1) 1.23 -1.24 1.51 -1.26
Platelet derived growth factor receptor, beta polypeptide (Pdgfrb) -1.42 1.02 -1.50 1.07
Transport     
Chloride channel 2 (Clcn2) -1.39 1.05 -1.07 1.06
Solute carrier family 12, member 1 (Slc12a1) -1.57 1.02 -1.04 1.26
Transcription     
Nuclear antigen Sp100 (Sp100) -1.55 1.11 -1.32 1.00
Chromatin accessibility complex 1 (Chrac1) 1.47 1.07 1.03 -1.11
X-box binding protein 1 (Xbp1) 1.36 -1.14 1.18 -1.10
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated 1.29 1.07 1.30 1.04
Transcription factor E2a (Tcfe2a) -1.29 -1.02 -1.35 -1.08
Structure     
LIM-domain containing, protein kinase (Limk1) 1.49 1.06 1.30 -1.14
DIX domain containing 1 (Dixdc1) -1.31 1.20 -1.41 1.16
Ankyrin 3, epithelial (Ank3), transcript variant 1 -1.14 1.09 -1.27 1.10
Oncogene, tumour suppressor     
B-cell leukemia/lymphoma 3 (Bcl3) 1.73 1.00 2.13 -1.15
T-cell lymphoma invasion and metastasis 1 (Tiam1) -1.19 1.13 -1.45 1.10
Kruppel-like factor 9 (Klf9) 1.02 -1.47 1.01 -1.32
Others     
Growth arrest and DNA-damage-inducible 45 gamma (Gadd45g) 1.21 -1.01 1.95 -1.18
Enoyl Coenzyme A hydratase domain containing 3 (Echdc3) -1.50 1.13 -1.12 1.13
Cathepsin D (Ctsd) 1.54 -1.05 1.46 1.03
Angiomotin like 2 (Amotl2) 1.47 1.15 -1.02 -1.02
Glucose-6-phosphate dehydrogenase X-linked (G6pdx) 1.42 -1.00 1.20 -1.05
TG interacting factor (Tgif) -1.06 1.07 1.33 -1.01
Nucleolar protein 5A (Nol5a) 1.31 1.02 1.03 -1.10
Protein-O-mannosyltransferase 1 (Pomt1) -1.24 1.02 -1.03 1.05
Chitinase 3-like 3 (Chi3l3) 3.19 -1.12 2.91 1.25
Leukotriene C4 synthase (Ltc4s) 1.81 -1.06 1.19 1.10
ATPase, H+ transporting, V0 subunit D, isoform 2 (Atp6v0d2) 1.76 -1.15 1.58 -1.13
Cold inducible RNA binding protein (Cirbp) -1.48 1.14 -1.58 1.06
Unknown and RIKENS     
Lung-inducible neuralized-related C3HC4 RING domain protein (Lincr) 1.45 1.08 1.22 -1.04
Selenocysteine lyase (Scly) -1.29 1.14 -1.26 1.00
RIKEN cDNA B230118H07 gene -1.07 1.08 -1.29 1.12
RIKEN cDNA 1110019L22 gene 1.13 1.02 -1.22 -1.27
Zinc finger CCCH type, antiviral 1 (Zc3hav1) -1.33 -1.06 -1.18 -1.02
RIKEN cDNA 9830165K03 -1.40 1.12 -1.18 1.02
RIKEN cDNA 2310007H09 gene -1.38 1.11 -1.07 1.11
mRNA for mKIAA1201 protein -1.31 1.09 -1.36 1.00
Oolfactory receptor 1286 (Olfr1286) -1.87 1.17 1.06 -1.04
Procollagen, type III, alpha 1 (Col3a1) -1.59 -1.05 -1.77 1.17
RIKEN cDNA 1190002H23 gene -1.25 -1.14 1.73 -1.06
4 days neonate male adipose cDNA, RIKEN 1.23 -1.54 1.15 -1.70
Roundabout homolog 2 (Drosophila) (Robo2) -1.66 1.04 -1.18 1.22
Adult male urinary bladder cDNA, RIKEN 1.11 1.12 -1.04 -1.64
RIKEN cDNA 1700012B18 gene 1.33 -1.23 2.25 -1.21
Btg3 associated nuclear protein (Banp) -1.36 -1.48 1.16 1.06
RIKEN cDNA 9130213B05 gene 1.39 1.00 1.52 -1.01
E74-like factor 3 (Elf3) 1.51 1.03 1.47 1.06
  1. * 1. 6 weeks smoke, 2. 6 weeks smoke followed by 6 weeks break, 3. 12 weeks smoke
  2. 4. 12 weeks smoke followed by 6 weeks break