TY - JOUR AU - Nehmé, Alissar AU - Lobenhofer, Edward K. AU - Stamer, W. Daniel AU - Edelman, Jeffrey L. PY - 2009 DA - 2009/09/10 TI - Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells JO - BMC Medical Genomics SP - 58 VL - 2 IS - 1 AB - In addition to their well-documented ocular therapeutic effects, glucocorticoids (GCs) can cause sight-threatening side-effects including ocular hypertension presumably via morphological and biochemical changes in trabecular meshwork (TM) cells. In the present study, we directly compared the glucocorticoid receptor (GR) potency for dexamethasone (DEX), fluocinolone acetonide (FA) and triamcinolone acetonide (TA), examined the expression of known GRα and GRβ isoforms, and used gene expression microarrays to compare the effects of DEX, FA, and TA on the complete transcriptome in two primary human TM cell lines. SN - 1755-8794 UR - https://doi.org/10.1186/1755-8794-2-58 DO - 10.1186/1755-8794-2-58 ID - Nehmé2009 ER -