Ligand | IC50
(nM) | Ki
(nM) |
n
H
|
---|
Dexamethasone | 5.36 ± 1.13 | 2.68 ± 0.58 | 1.06 ± 0.18 |
Fluocinolone acetonide | 2.00 ± 0.42 | 0.97 ± 0.17 | 1.10 ± 0.00 |
Triamcinolone acetonide | 1.45 ± 0.50 | 0.72 ± 0.24 | 1.05 ± 0.07 |
- IC50, Ki, and n
H
values were determined using a glucocorticoid receptor radiolabeled competition binding assay as described in "Materials and methods" section.
- Data shown for dexamethasone are averages of fourteen independent experiments performed in triplicate ± SD.
- Data shown for fluocinolone acetonide and triamcinolone acetonide are averages of two independent experiments performed in triplicate ± SD.