Skip to main content

Table 1 Glucocorticoid receptor binding affinity for dexamethasone, fluocinolone acetonide, and triamcinolone acetonide.

From: Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells

Ligand

IC50

(nM)

Ki

(nM)

n H

Dexamethasone

5.36 ± 1.13

2.68 ± 0.58

1.06 ± 0.18

Fluocinolone acetonide

2.00 ± 0.42

0.97 ± 0.17

1.10 ± 0.00

Triamcinolone acetonide

1.45 ± 0.50

0.72 ± 0.24

1.05 ± 0.07

  1. IC50, Ki, and n H values were determined using a glucocorticoid receptor radiolabeled competition binding assay as described in "Materials and methods" section.
  2. Data shown for dexamethasone are averages of fourteen independent experiments performed in triplicate ± SD.
  3. Data shown for fluocinolone acetonide and triamcinolone acetonide are averages of two independent experiments performed in triplicate ± SD.