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Table 3 Top 24 differentially regulated genes in response to DEX, FA, or TA treatment in TM 93 cell line.

From: Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells

Gene Symbol

Gene Name

GenBank Accession Number

DEX

FC

FA

FC

TA

FC

UPREGULATED

     

OCA2

oculocutaneous albinism II

NM_000275

>100

98.0

>100

ANGPTL7

Angiopoietin-like 7

NM_021146

18.8

13.0

20.5

RGC32

Response gene to complement 32

NM_014059

18.8

11.0

19.9

LSP1

clone pp9372 unknown mRNA

AF289610

NS

18.0

NS

SAA1

Serum amyloid A1

NM_000331

10.7

8.3

11.9

KCNB1

Potassium voltage-gated channel, Shab-related subfamily, member 1

NM_004975

9.3

5.2

11.3

ITGA10

Integrin, alpha 10

NM_003637

8.1

9.1

5.6

ANGPTL4

Angiopoietin-like 4

NM_139314

6.5

9.1

5.3

FKBP5

FK506 binding protein 5

NM_004117

5.9

6.8

5.8

PF4

platelet factor 4 (chemokine (C-X-C motif) ligand 4)

NM_002619

5.2

6.5

4.4

ZBTB16

Zinc finger and BTB domain containing 16

NM_006006

5.4

4.9

5.5

KLF15

Kruppel-like factor 15

NM_014079

4.2

3.6

3.9

MYOC

Myocilin, trabecular meshwork inducible glucocorticoid response

NM_000261

2.5

2.7

2.6

DOWNREGULATED

     

ENST00000344214

Unknown

Unknown

-5.6

-6.3

NS

KAL1

Kallmann syndrome 1 sequence

NM_000216

-2.9

-3.0

-3.3

GABRB1

Gamma-aminobutyric acid (GABA) A receptor, beta 1

NM_000812

-2.5

-2.2

-2.6

AQP1

Aquaporin 1 (Colton blood group)

NM_198098

-2.8

-3.2

-2.8

MXRA5

Matrix-remodelling associated 5

NM_015419

-3.9

-4.5

-4.5

PCDH19

Protocadherin 19

NM_020766

-2.9

-3.9

-3.3

PER3

Period homolog 3 (Drosophila)

NM_016831

-2.8

-3.6

-3.8

CCRL1

Chemokine (C-C motif) receptor-like 1

NM_178445

-2.4

-2.5

-2.1

KIF4A

Kinesin family member 4A

NM_012310

-2.3

-2.2

-2.3

CXADR

Coxsackie virus and adenovirus receptor

NM_001338

-2.2

-1.8

-2.6

RASL11B

RAS-like, family 11, member B

NM_023940

-1.5

NS

NS

  1. FC: fold change; NS: not significant
  2. The genes are listed according to their rank order fold-change.