Gene expression meta-analysis supports existence of molecular apocrine breast cancer with a role for androgen receptor and implies interactions with ErbB family

Table 1 Top-ranking Gene Ontology categories identified by LeFEminer on the normalized index cohorts

Category. Rank	Category. Name	Category. Size
1	carboxylic acid metabolism	138
1	Fatty acid metabolism	47
1	Fatty acid metabolism BioCarta	24
1	MAP00480 Glutathione metabolism GenMAPP	18
5	organic acid metabolism	140
5	aromatic compound catabolism	6
5	MAP00350 Tyrosine metabolism GenMAPP	29
8	oxidoreductase activity, acting on CH-OH group of donors	44
9	aromatic amino acid family catabolism	5
10	electron transporter activity BioCarta	102
11	Cyclic nucleotide-dependent protein kinase activity	4
11	ANDROGEN UP GENES na	56
13	tyrosine catabolism	3
13	Fatty Acid Synthesis BioCarta	14
15	regulation of locomotion	6
16	acetylgalactosaminyltransferase activity	7
16	polypeptide N-acetylgalactosaminyltransferase activity	7
16	MAP00360 Phenylalanine metabolism GenMAPP	16
19	breast cancer estrogen signalling GEArray	92
20	peroxisome	36
20	MAP00512 O Glycans biosynthesis GenMAPP	7
22	amine catabolism	23
22	cAMP-dependent protein kinase activity	4
24	regulation of cell migration	6
24	microtubule cytoskeleton organization and biogenesis	23
24	mitotic spindle checkpoint	2
24	electron transporter activity	114
24	Microbody	36
29	regulation of behaviour	6
29	neuronal lineage restriction	2

Rank determined by p-value and false discovery rate. All categories shown in table were identified with 0% false discovery rate. The Category. Size column lists the number of genes in the pre-defined dataset representative of the GO category.

ISSN: 1755-8794