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Table 1 Top 5 significantly over-represented GO terms of 'molecular function' and 'biological process' in cancer genes vs. non-cancer genes

From: Discovering cancer genes by integrating network and functional properties

GO_ID

# cancer genes

# non-cancer genes

chi-square

p-value

Name

Name space

45786

35

243

260.6

1.30E-58

negative regulation of cell cycle

biological_process

6974

34

244

259.4

2.30E-58

response to DNA damage stimulus

biological_process

50794

181

97

238.8

7.20E-54

regulation of cellular process

biological_process

9719

35

243

235.2

4.29E-53

response to endogenous stimulus

biological_process

6468

42

236

232.8

1.49E-52

protein amino acid phosphorylation

biological_process

4713

25

253

280.7

5.37E-63

protein-tyrosine kinase activity

molecular_function

3677

122

156

195.7

1.82E-44

DNA binding

molecular_function

4672

38

240

193.8

4.78E-44

protein kinase activity

molecular_function

30528

95

183

173.0

1.60E-39

Transcription regulator activity

molecular_function

16733

39

239

154.8

1.54E-35

phosphotransferase activity, alcohol group as acceptor

molecular_function