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Table 2 Top 10 significantly over-represented Pfam domains in cancer genes vs. non-cancer genes

From: Discovering cancer genes by integrating network and functional properties

ID

# cancer genes

# non-cancer genes

Chi-square

p-value

Name

Description

PF07714

25

21

245.2

2.88E-55

Pkinase_Tyr

Protein tyrosine kinase

PF00069

31

54

188.2

8.03E-43

Pkinase

Protein kinase domain

PF00178

7

0

122.1

2.17E-28

Ets

Ets-domain

PF00292

4

0

61.5

4.36E-15

PAX

'Paired box' domain

PF00270

7

10

43.0

5.42E-11

DEAD

DEAD/DEAH box helicase

PF01119

3

0

41.6

1.11E-10

DNA_mis_repair

DNA mismatch repair protein, C-terminal domain

PF02518

5

4

41.5

1.18E-10

HATPase_c

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

PF00017

9

20

39.6

3.08E-10

SH2

SH2 domain

PF00855

5

5

36.5

1.53E-09

PWWP

PWWP domain

PF00046

17

90

28.2

1.11E-07

Homeobox

Homeobox domain