IPA analysis of genes with Diagnosis × Probeset effects identified a network of 22 genes. Red indicates genes upregulated in schizophrenia, green indicates genes down-regulated in schizophrenia. White indicates the genes were not part of the dataset file genes. Solid lines indicate direct interactions, while dashed lines indicate indirect interactions. See Figure 4 legend for description of molecular classes indicated by each network shape. The network included 22 genes that showed diagnosis effects on gene expression. Interestingly, calcium-activated calmodulin, which has previously been shown to be altered in expression in schizophrenia , was a centrally located complex within this network.