Table 2 Top 59 genes differentially expressed in sinonasal adenocarcinomas after two-class comparison analysis

LGALS4

Up-regulated genes

lectin, galactoside-binding, soluble, 4 (galectin 4)

3.084

ACS5

fatty-acid-Coenzyme A ligase, long-chain 5

2.621

COL4A1

collagen, type IV, alpha 1

1.779

JUN

v-jun sarcoma virus 17 oncogene homolog (avian)

1.758

CEACAM8

carcinoembryonic antigen-related cell adhesion molecule 8

1.732

ADFP

adipose differentiation-related protein

1.628

similar to 60 kDa heat shock protein, mitochondrialprecursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein60) (HSP-60)

1.617

CCL20

chemokine (C-C motif) ligand 20

1.560

TGFBI

transforming growth factor, beta-induced, 68 kDa

1.493

COL5A2

collagen, type V, alpha 2

1.461

SRI

sorcin

1.456

ANXA4

annexin A4

1.434

LDHA

lactate dehydrogenase A

1.416

STMN1

stathmin 1/oncoprotein 18

1.414

PLEKHB2

pleckstrin homology domain containing, family B (evectins) member 2

1.409

similar to Cytochrome c, somatic (LOC164837), mRNA.

1.387

MRPL13

mitochondrial ribosomal protein L13

1.370

HSPD1

heat shock 60 kDa protein 1 (chaperonin)

1.346

YWHAZ

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

1.342

ACAA2

acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)

1.335

MRPS35

mitochondrial ribosomal protein S35

1.329

PCNA

proliferating cell nuclear antigen

1.319

CKS2

CDC28 protein kinase regulatory subunit 2

1.278

TPM3

tropomyosin 3

1.224

DHRS8

dehydrogenase/reductase (SDR family) member 8

1.206

CASP6

caspase 6, apoptosis-related cysteine protease

1.194

PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2

1.172

similar to cytochrome c (LOC157317), mRNA.

1.164

ENO1

enolase 1, (alpha)

1.145

similar to cytochrome C, expressed in somatic tissues(LOC128146), mRNA.

1.133

CKLF

chemokine-like factor

1.133

ENO1

enolase 1, (alpha)

1.121

ARPC1B

actin related protein 2/3 complex, subunit 1B, 41 kDa

1.114

PPIA

peptidylprolyl isomerase A (cyclophilin A)

1.110

CLIC1

chloride intracellular channel 1

1.095

CYCS

cytochrome c, somatic

1.081

XRN2

5'-3' exoribonuclease 2

1.068

HSPD1

heat shock 60 kDa protein 1 (chaperonin)

1.066

PSMA7

proteasome (prosome, macropain) subunit, alpha type, 7

1.044

TEBP

unactive progesterone receptor, 23 kD

1.037

CBX3

chromobox homolog 3 (HP1 gamma homolog, Drosophila)

1.023

CKS1B

CDC28 protein kinase regulatory subunit 1B

1.013

MYCN

v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)

1.006

Down-regulated genes

CLU

clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)

-3.606

S100A2

S100 calcium binding protein A2

-2.152

AKR1C1

aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)

-2.102

PPAP2B

phosphatidic acid phosphatase type 2B

-1.966

PPAP2B

phosphatidic acid phosphatase type 2B

-1.936

CSRP2

cysteine and glycine-rich protein 2

-1.916

FBLN1

fibulin 1

-1.799

CRYAB

crystallin, alpha B

-1.590

PTN

pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)

-1.405

TF

transferrin

-1.256

SEMA3F

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F

-1.246

KRT5

keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)

-1.207

PLK2

polo-like kinase 2 (Drosophila)

-1.186

NFIB

nuclear factor I/B

-1.149

PDGFRA

platelet-derived growth factor receptor, alpha polypeptide

-1.090

MADH1

MAD, mothers against decapentaplegic homolog 1 (Drosophila)

-1.047