Table 1 Differentially expressed genes (>2 Fold) in response to HDACi in HCT116 colon cancer cells.
| Â | Â | Â | HCT116 | |
|---|---|---|---|---|
Accession # | Gene Symbol | Gene Name | Fold Change | P-Value |
Induced | Â | Â | LBH589 | |
NM_001901.2 | CTGF | Connective tissue growth factor | 6.09 | 6.9E-04 |
NM_182908.3 | DHRS2 | Dehydrogenase/reductase member 2 | 4.78 | 1.7E-04 |
NM_003378.2 | VGF | VGF nerve growth factor inducible | 4.74 | 1.0E-04 |
NM_183376.1 | ARRDC4 | Arrestin domain containing 4 | 4.15 | 6.9E-04 |
NM_173798.2 | ZCCHC12 | Zinc finger, CCHC domain containing 12 | 4.13 | 1.8E-05 |
NM_006865.2 | LILRA3 | Leukocyte immunoglobulin-like receptor, subfamily A, member 3 | 3.94 | 7.2E-05 |
NM_033184.2 | KRTAP2-4 | Keratin associated protein 2-4 | 3.61 | 7.2E-04 |
NM_000558.3 | HBA1 | Hemoglobin, alpha 1 | 3.60 | 3.2E-04 |
NM_016352.3 | CPA4 | Carboxypeptidase A4 | 3.47 | 2.7E-04 |
NM_001554.4 | CYR61 | Cysteine-rich, angiogenic inducer, 61 | 3.44 | 2.7E-05 |
NM_005319.3 | HIST1H1C | Histone 1, H1c | 3.37 | 9.9E-05 |
NM_138720.1 | HIST1H2BD | Histone 1, H2bd | 3.35 | 2.2E-04 |
NM_031476.1 | CRISPLD2 | Cysteine-rich secretory protein LCCL domain containing 2 | 3.26 | 8.4E-05 |
NM_139072.2 | DNER | Delta-notch-like EGF repeat-containing transmembrane | 3.21 | 1.5E-03 |
NM_005061.2 | RPL3L | Ribosomal protein L3-like | 3.08 | 2.5E-05 |
Repressed | Â | Â | Â | Â |
NM_013233.2 | STK39 | Serine threonine kinase 39 | -2.91 | 8.2E-04 |
NM_004091.2 | E2F2 | E2F transcription factor 2 | -2.93 | 2.4E-04 |
NM_003302.1 | TRIP6 | Thyroid hormone receptor interactor 6 | -2.99 | 7.3E-04 |
NM_005733.2 | KIF20A | Kinesin family member 20A | -3.00 | 2.2E-05 |
NM_005329.2 | HAS3 | Hyaluronan synthase 3 | -3.02 | 4.1E-05 |
NM_145810.1 | CDCA7 | Cell division cycle associated 7 | -3.06 | 2.4E-03 |
NM_005434.4 | MALL | Mal, T-cell differentiation protein-like | -3.07 | 2.8E-04 |
NM_002129.2 | HMGB2 | High-mobility group box 2 | -3.13 | 3.6E-03 |
NM_018649.2 | H2AFY2 | H2A histone family, member Y2 | -3.28 | 8.7E-04 |
NM_001038.5 | SCNN1A | Sodium channel, nonvoltage-gated 1 | -3.59 | 6.6E-04 |
NM_004217.2 | AURKB | Aurora kinase B | -3.61 | 5.4E-04 |
NM_001237.3 | CCNA2 | Cyclin A2 | -3.72 | 2.9E-05 |
NM_001071.1 | TYMS | Thymidylate synthase | -3.88 | 1.1E-04 |
NM_181803.1 | UBE2C | Ubiquitin-conjugating enzyme E2C | -3.95 | 2.6E-04 |
NM_001423.2 | EMP1 | Epithelial membrane protein 1 | -4.17 | 1.3E-05 |
Induced | Â | Â | Vorinostat | |
NM_001901.2 | CTGF | Connective tissue growth factor | 4.76 | 2.0E-05 |
NM_003378.2 | VGF | VGF nerve growth factor inducible | 4.35 | 1.8E-03 |
NM_182908.3 | DHRS2 | Dehydrogenase/reductase member 2 | 4.05 | 6.2E-04 |
NM_183376.1 | ARRDC4 | Arrestin domain containing 4 | 3.35 | 4.4E-04 |
NM_173798.2 | ZCCHC12 | Zinc finger, CCHC domain containing 12 | 3.27 | 1.7E-06 |
NM_016352.3 | CPA4 | Carboxypeptidase A4 | 2.91 | 1.0E-03 |
NM_017445.1 | H2BFS | H2B histone family, member S | 2.86 | 2.8E-04 |
NM_138720.1 | HIST1H2BD | Histone 1, H2bd | 2.85 | 1.6E-04 |
NM_033184.2 | KRTAP2-4 | Keratin associated protein 2-4 | 2.81 | 2.6E-03 |
NM_001554.4 | CYR61 | Cysteine-rich, angiogenic inducer, 61 | 2.73 | 1.3E-05 |
NM_139072.2 | DNER | Delta-notch-like EGF repeat-containing transmembrane | 2.62 | 2.2E-03 |
NM_005319.3 | HIST1H1C | Histone 1, H1c | 2.57 | 5.4E-04 |
NM_006865.2 | LILRA3 | Leukocyte immunoglobulin-like receptor, subfamily A, member 3 | 2.37 | 1.2E-03 |
NM_005952.2 | MT1X | Metallothionein 1× | 2.37 | 1.2E-03 |
NM_080593.1 | HIST1H2BK | Histone 1, H2bk | 2.36 | 9.2E-06 |
NM_005950.1 | MT1G | Metallothionein 1G | 2.33 | 7.4E-03 |
Repressed | Â | Â | Â | Â |
NM_003998.2 | NFKB1 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | -2.04 | 6.9E-04 |
NM_018043.5 | TMEM16A | Transmembrane protein 16A | -2.05 | 1.6E-03 |
NM_003302.1 | TRIP6 | Thyroid hormone receptor interactor 6 | -2.08 | 6.6E-03 |
NM_145810.1 | CDCA7 | Cell division cycle associated 7 | -2.08 | 2.4E-03 |
NM_004217.2 | AURKB | Aurora kinase B | -2.08 | 1.7E-03 |
NM_001235.2 | SERPINH1 | Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1 | -2.11 | 7.4E-05 |
NM_001425.2 | EMP3 | Epithelial membrane protein 3 | -2.11 | 1.0E-03 |
NM_005329.2 | HAS3 | Hyaluronan synthase 3 | -2.11 | 2.4E-05 |
NM_001237.3 | CCNA2 | Cyclin A2 | -2.15 | 1.5E-03 |
NM_002129.2 | HMGB2 | High-mobility group box 2 | -2.17 | 1.3E-03 |
NM_005434.4 | MALL | Mal, T-cell differentiation protein-like | -2.17 | 4.2E-04 |
NM_001423.2 | EMP1 | Epithelial membrane protein 1 | -2.23 | 1.6E-04 |
NM_181803.1 | UBE2C | Ubiquitin-conjugating enzyme E2C | -2.31 | 3.1E-04 |
NM_018649.2 | H2AFY2 | H2A histone family, member Y2 | -2.51 | 2.2E-06 |
NM_001071.1 | TYMS | Thymidylate synthase | -2.74 | 7.4E-06 |